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Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder.

 Eunjoo Kim  ;  Sunghyon Kyeong  ;  Keun-Ah Cheon  ;  Bumhee Park  ;  Maeng-Keun Oh  ;  Ji Won Chun  ;  Hae-Jeong Park  ;  Jae-Jin Kim  ;  Dong-Ho Song 
 NEUROSCIENCE LETTERS, Vol.621 : 117-125, 2016 
Journal Title
Issue Date
Adolescent ; Affect* ; Autism Spectrum Disorder/physiopathology* ; Autism Spectrum Disorder/psychology ; Brain/physiopathology ; Brain Mapping ; Child ; Cognition* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Theory of Mind*
Affective ToM ; Autism spectrum disorder ; Cognitive ToM ; Functional MRI ; Theory of mind
Children and adolescents with Autism Spectrum Disorder (ASD) are characterized by an impaired Theory of Mind (ToM). Recent evidence suggested that two aspects of ToM (cognitive ToM versus affective ToM) are differentially impaired in individuals with ASD. In this study, we examined the neural correlates of cognitive and affective ToM in children and adolescents with ASD compared to typically developing children (TDCs). Twelve children and adolescents with ASD and 12 age, IQ matched TDCs participated in this functional MRI study. The ToM task involved the attribution of cognitive and affective mental states to a cartoon character based on verbal and eye-gaze cues. In cognitive ToM tasks, ASD participants recruited the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and superior temporal gyrus (STG) to a greater extent than did TDCs. In affective ToM tasks, both ASD and TDC participants showed more activation in the insula and other subcortical regions than in cognitive ToM tasks. Correlational analysis revealed that greater activation of the mPFC/ACC regions was associated with less symptom severity in ASD patients. In sum, our study suggests that the recruitment of additional prefrontal resources can compensate for the successful behavioral performance in the ToM task in ASD participants.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun Joo(김은주) ORCID logo https://orcid.org/0000-0003-3061-2051
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Oh, Maeng Keun(오맹근)
Cheon, Keun Ah(천근아) ORCID logo https://orcid.org/0000-0001-7113-9286
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