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Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder.

DC FieldValueLanguage
dc.contributor.author김은주-
dc.contributor.author김재진-
dc.contributor.author박해정-
dc.contributor.author송동호-
dc.contributor.author오맹근-
dc.contributor.author천근아-
dc.date.accessioned2017-02-24T11:40:37Z-
dc.date.available2017-02-24T11:40:37Z-
dc.date.issued2016-
dc.identifier.issn0304-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146830-
dc.description.abstractChildren and adolescents with Autism Spectrum Disorder (ASD) are characterized by an impaired Theory of Mind (ToM). Recent evidence suggested that two aspects of ToM (cognitive ToM versus affective ToM) are differentially impaired in individuals with ASD. In this study, we examined the neural correlates of cognitive and affective ToM in children and adolescents with ASD compared to typically developing children (TDCs). Twelve children and adolescents with ASD and 12 age, IQ matched TDCs participated in this functional MRI study. The ToM task involved the attribution of cognitive and affective mental states to a cartoon character based on verbal and eye-gaze cues. In cognitive ToM tasks, ASD participants recruited the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and superior temporal gyrus (STG) to a greater extent than did TDCs. In affective ToM tasks, both ASD and TDC participants showed more activation in the insula and other subcortical regions than in cognitive ToM tasks. Correlational analysis revealed that greater activation of the mPFC/ACC regions was associated with less symptom severity in ASD patients. In sum, our study suggests that the recruitment of additional prefrontal resources can compensate for the successful behavioral performance in the ToM task in ASD participants.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent117~125-
dc.languageEnglish-
dc.publisherElsevier Scientific Publishers Ireland-
dc.relation.isPartOfNEUROSCIENCE LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAffect*-
dc.subject.MESHAutism Spectrum Disorder/physiopathology*-
dc.subject.MESHAutism Spectrum Disorder/psychology-
dc.subject.MESHBrain/physiopathology-
dc.subject.MESHBrain Mapping-
dc.subject.MESHChild-
dc.subject.MESHCognition*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHTheory of Mind*-
dc.titleNeural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder.-
dc.typeArticle-
dc.publisher.locationIreland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorEunjoo Kim-
dc.contributor.googleauthorSunghyon Kyeong-
dc.contributor.googleauthorKeun-Ah Cheon-
dc.contributor.googleauthorBumhee Park-
dc.contributor.googleauthorMaeng-Keun Oh-
dc.contributor.googleauthorJi Won Chun-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorJae-Jin Kim-
dc.contributor.googleauthorDong-Ho Song-
dc.identifier.doi10.1016/j.neulet.2016.04.026-
dc.contributor.localIdA00820-
dc.contributor.localIdA00870-
dc.contributor.localIdA01730-
dc.contributor.localIdA02018-
dc.contributor.localIdA04604-
dc.contributor.localIdA04027-
dc.relation.journalcodeJ02364-
dc.identifier.eissn1872-7972-
dc.identifier.pmid27084690-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0304394016302312-
dc.subject.keywordAffective ToM-
dc.subject.keywordAutism spectrum disorder-
dc.subject.keywordCognitive ToM-
dc.subject.keywordFunctional MRI-
dc.subject.keywordTheory of mind-
dc.contributor.alternativeNameKim, Eun Joo-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.alternativeNameSong, Dong Ho-
dc.contributor.alternativeNameOh, Maeng Keun-
dc.contributor.alternativeNameCheon, Keun Ah-
dc.contributor.affiliatedAuthorKim, Eun Joo-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.contributor.affiliatedAuthorSong, Dong Ho-
dc.contributor.affiliatedAuthorOh, Maeng Keun-
dc.contributor.affiliatedAuthorCheon, Keun Ah-
dc.citation.volume621-
dc.citation.startPage117-
dc.citation.endPage125-
dc.identifier.bibliographicCitationNEUROSCIENCE LETTERS, Vol.621 : 117-125, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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