Cited 14 times in
Differentiation between borderline and benign ovarian tumors: combined analysis of MRI with tumor markers for large cystic masses (≥5 cm).
DC Field | Value | Language |
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dc.contributor.author | 박성윤 | - |
dc.contributor.author | 오영택 | - |
dc.contributor.author | 정대철 | - |
dc.date.accessioned | 2017-02-24T11:38:54Z | - |
dc.date.available | 2017-02-24T11:38:54Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0284-1851 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146822 | - |
dc.description.abstract | BACKGROUND: There is overlap in imaging features between borderline and benign ovarian tumors. PURPOSE: To analyze diagnostic performance of magnetic resonance imaging (MRI) combined with tumor markers for differentiating borderline from benign ovarian tumor. MATERIAL AND METHODS: Ninety-nine patient with MRI and surgically confirmed ovarian tumors 5 cm or larger (borderline, n = 37; benign, n = 62) were included. On MRI, tumor size, septal number (0; 1-4; 5 or more), and presence of solid portion such as papillary projection or septal thickening 0.5 cm or larger were investigated. Serum tumor markers (carbohydrate antigen 125 [CA 125] and CA 19-9) were recorded. Multivariate analysis was conducted for assessing whether combined MRI with tumor markers could differentiate borderline from benign tumor. The diagnostic performance was also analyzed. RESULTS: Incidence of solid portion was 67.6% (25/37) in borderline and 3.2% (2/62) in benign tumors (P < 0.05). In all patients, without combined analysis of MRI with tumor markers, multivariate analysis revealed solid portion (P < 0.001) and CA 125 (P = 0.039) were significant for predicting borderline tumors. When combined analysis of MRI with CA 125 ((i) the presence of solid portion or (ii) CA 125 > 44.1 U/mL with septal number ≥5 for borderline tumor) is incorporated to multivariate analysis, it was only significant (P = 0.001). The sensitivity, specificity, PPV, NPV, and accuracy of combined analysis of MRI with CA 125 were 89.1%, 91.9%, 86.8%, 93.4, and 90.9%, respectively. CONCLUSION: Combined analysis of MRI with CA 125 may allow better differentiation between borderline and benign ovarian tumor compared with MRI alone. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 633~639 | - |
dc.publisher | Sage | - |
dc.relation.isPartOf | ACTA RADIOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | CA-125 Antigen/analysis* | - |
dc.subject.MESH | CA-19-9 Antigen/analysis* | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Meglumine | - |
dc.subject.MESH | Organometallic Compounds | - |
dc.subject.MESH | Ovarian Neoplasms/pathology* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.title | Differentiation between borderline and benign ovarian tumors: combined analysis of MRI with tumor markers for large cystic masses (≥5 cm). | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Sung Yoon Park | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Dae Chul Jung | - |
dc.identifier.doi | 10.1177/0284185115597266 | - |
dc.contributor.localId | A01509 | - |
dc.contributor.localId | A02390 | - |
dc.contributor.localId | A03592 | - |
dc.relation.journalcode | J00033 | - |
dc.identifier.eissn | 1600-0455 | - |
dc.identifier.pmid | 26231948 | - |
dc.identifier.url | http://acr.sagepub.com/content/57/5/633 | - |
dc.subject.keyword | Borderline tumor | - |
dc.subject.keyword | CA 125 | - |
dc.subject.keyword | magnetic resonance imaging (MRI) | - |
dc.subject.keyword | ovary | - |
dc.subject.keyword | tumor marker | - |
dc.contributor.alternativeName | Park, Sung Yoon | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.alternativeName | Jung, Dae Chul | - |
dc.contributor.affiliatedAuthor | Park, Sung Yoon | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Jung, Dae Chul | - |
dc.citation.volume | 57 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 639 | - |
dc.identifier.bibliographicCitation | ACTA RADIOLOGICA, Vol.57(5) : 633-639, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47564 | - |
dc.type.rims | ART | - |
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