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Effects of Omega-3 Fatty Acid Supplementation on Diabetic Nephropathy Progression in Patients with Diabetes and Hypertriglyceridemia.

 Eugene Han  ;  Yujung Yun  ;  Gyuri Kim  ;  Yong-ho Lee  ;  Hye Jin Wang  ;  Byung Wan Lee  ;  Bong Soo Cha  ;  Beom Seok Kim  ;  Eun Seok Kang 
 PLOS ONE, Vol.11(5) : e0154683, 2016 
Journal Title
Issue Date
Aged ; Albuminuria/drug therapy ; Diabetes Mellitus/drug therapy* ; Diabetic Nephropathies/drug therapy* ; Disease Progression ; Fatty Acids, Omega-3/therapeutic use* ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Hypertriglyceridemia/drug therapy* ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies
Beneficial effects of omega-3 fatty acid (O3FA) supplementation in a wide range of disease condition have been well studied. However, there is limited information regarding the effects of O3FAs on chronic kidney disease (CKD), especially in diabetic nephropathy (DN) with hypertriglyceridemia. We investigate whether O3FA supplementation could help maintain renal function in patients with diabetes and hypertriglyceridemia. Total 344 type 2 diabetic patients with a history of O3FA supplementation for managing hypertriglyceridemia were included. Reduction in urine albumin to creatinine ratio (ACR) and glomerular filtrate rate (GFR) were examined. Subgroup analyses were stratified according to the daily O3FA doses. Serum total cholesterol, triglyceride, and urine ACR significantly reduced after O3FA supplementation. Overall, 172 (50.0%) patients did not experience renal function loss, and 125 (36.3%) patients had a GFR with a positive slope. The patients treated with O3FAs at 4g/day showed greater maintenance in renal function than those treated with lower dosages (p < 0.001). This dose dependent effect remains significant after adjustment for multiple variables. O3FA supplementation in diabetic patients with hypertriglyceridemia shows benefits of reducing albuminuria and maintaining renal function. The effects are dependent on the dose of daily O3FA supplementation.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Kim, Gyuri(김규리)
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Wang, Hye Jin(왕혜진)
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
Han, Eu Gene(한유진)
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