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Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction.

 Sang Won Han  ;  Tae Jin Song  ;  Cheryl D. Bushnell  ;  Sung-Soo Lee  ;  Seo Hyun Kim  ;  Jun Hong Lee  ;  Gyu Sik Kim  ;  Ok-Joon Kim  ;  Im-Seok Koh  ;  Jong Yun Lee  ;  Seung-Han Suk  ;  Sung Ik Lee  ;  Hyo Suk Nam  ;  Kyung-Yul Lee  ;  Jae Hyeon Park 
 JOURNAL OF NEUROIMAGING, Vol.26(3) : 351-354, 2016 
Journal Title
Issue Date
Aged ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pulsatile Flow/drug effects* ; Pulsatile Flow/physiology* ; Statistics as Topic ; Stroke, Lacunar/blood* ; Stroke, Lacunar/diagnostic imaging* ; Stroke, Lacunar/drug therapy ; Tetrazoles/therapeutic use* ; Ultrasonography, Doppler, Transcranial/drug effects ; Uric Acid/blood* ; White Matter/diagnostic imaging* ; White Matter/drug effects
Lacunar infarcts ; uric acid ; white matter hyperintensities
BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm(3) (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction. Copyright © 2015 by the American Society of Neuroimaging.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Lee, Kyung Yul(이경열) ORCID logo https://orcid.org/0000-0001-5585-7739
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