Cited 8 times in
Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남효석 | - |
dc.contributor.author | 이경열 | - |
dc.date.accessioned | 2017-02-24T11:29:40Z | - |
dc.date.available | 2017-02-24T11:29:40Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1051-2284 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146782 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study showed a significant decrease in transcranial Doppler pulsatility index (PI) with cilostazol treatment after 90 days of acute lacunar infarction. The aim of this analysis was to perform a subgroup analysis of the ECLIPse study to explore the relationship between serum uric acid (UA) and the volume of white matter hyperintensities (WMH) in patients with acute lacunar infarction. METHODS: The ECLIPse was a multicenter, randomized, double-blind, placebo-controlled study conducted in Korea. For this subgroup analysis, WMH volume was measured for those subjects for whom FLAIR or T2-weighted images were available using semiautomated computerized software. RESULTS: Of the 203 patients in 8 hospitals in the ECLIPse study, 130 in 6 hospitals were entered for this subgroup analysis. The mean age was 64.7 ± 9.95 years, and 20.8% were women. The mean WMH volume was 11.57 cm(3) (.13 to 68.45, median 4.86) and mean serum UA was 5.2 mg/dL (1.5 to 8.9). Multiple linear regression analysis revealed that age (P < .001) and serum UA (P = .013) were significantly associated with WMH volume. Age-adjusted scatterplots showed that serum UA level was positively related to WMH volume in patients with acute lacunar infarction (r = 0.275, P = .003). CONCLUSIONS: This study showed that serum UA was associated with cerebral WMH in patients with acute lacunar infarction. Copyright © 2015 by the American Society of Neuroimaging. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 351~354 | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | JOURNAL OF NEUROIMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pulsatile Flow/drug effects* | - |
dc.subject.MESH | Pulsatile Flow/physiology* | - |
dc.subject.MESH | Statistics as Topic | - |
dc.subject.MESH | Stroke, Lacunar/blood* | - |
dc.subject.MESH | Stroke, Lacunar/diagnostic imaging* | - |
dc.subject.MESH | Stroke, Lacunar/drug therapy | - |
dc.subject.MESH | Tetrazoles/therapeutic use* | - |
dc.subject.MESH | Ultrasonography, Doppler, Transcranial/drug effects | - |
dc.subject.MESH | Uric Acid/blood* | - |
dc.subject.MESH | White Matter/diagnostic imaging* | - |
dc.subject.MESH | White Matter/drug effects | - |
dc.title | Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Tae Jin Song | - |
dc.contributor.googleauthor | Cheryl D. Bushnell | - |
dc.contributor.googleauthor | Sung-Soo Lee | - |
dc.contributor.googleauthor | Seo Hyun Kim | - |
dc.contributor.googleauthor | Jun Hong Lee | - |
dc.contributor.googleauthor | Gyu Sik Kim | - |
dc.contributor.googleauthor | Ok-Joon Kim | - |
dc.contributor.googleauthor | Im-Seok Koh | - |
dc.contributor.googleauthor | Jong Yun Lee | - |
dc.contributor.googleauthor | Seung-Han Suk | - |
dc.contributor.googleauthor | Sung Ik Lee | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Kyung-Yul Lee | - |
dc.contributor.googleauthor | Jae Hyeon Park | - |
dc.identifier.doi | 10.1111/jon.12308 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02648 | - |
dc.relation.journalcode | J01624 | - |
dc.identifier.eissn | 1552-6569 | - |
dc.identifier.pmid | 26458336 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jon.12308/abstract | - |
dc.subject.keyword | Lacunar infarcts | - |
dc.subject.keyword | uric acid | - |
dc.subject.keyword | white matter hyperintensities | - |
dc.contributor.alternativeName | Nam, Hyo Suk | - |
dc.contributor.alternativeName | Lee, Kyung Yul | - |
dc.contributor.affiliatedAuthor | Nam, Hyo Suk | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Yul | - |
dc.citation.volume | 26 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 351 | - |
dc.citation.endPage | 354 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROIMAGING, Vol.26(3) : 351-354, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47524 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.