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Elevated serum CA 19-9 levels in patients with pulmonary nontuberculous mycobacterial disease

 Ji Young Hong  ;  Sun Hee Jang  ;  Song Yee Kim  ;  Kyung Soo Chung  ;  Joo Han Song  ;  Moo Suk Park  ;  Young Sam Kim  ;  Se Kyu Kim  ;  Joon Chang  ;  Young Ae Kang 
 Brazilian Journal of Infectious Diseases, Vol.20(1) : 26-32, 2016 
Journal Title
 Brazilian Journal of Infectious Diseases 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Biomarkers/blood ; CA-19-9 Antigen/blood* ; Drug Therapy, Combination ; Female ; Humans ; Lung Diseases/blood* ; Lung Diseases/drug therapy ; Lung Diseases/microbiology ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/classification*
Biological marker ; Carbohydrate antigen 19-9 ; Nontuberculous mycobacteria ; Tuberculosis
Increased serum CA 19-9 levels in patients with nonmalignant diseases have been investigated in previous reports. This study evaluates the clinical significance of serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease and pulmonary tuberculosis. The median CA 19-9 level was higher in patients with pulmonary nontuberculous mycobacterial disease than in patients with pulmonary tuberculosis (pulmonary nontuberculous mycobacterial disease: 13.80, tuberculosis: 5.85, p<0.001). A multivariate logistic regression analysis performed in this study showed that Mycobacterium abscessus (OR 9.97, 95% CI: 1.58, 62.80; p=0.014) and active phase of pulmonary nontuberculous mycobacterial disease (OR 12.18, 95% CI: 1.07, 138.36, p=0.044) were found to be risk factors for serum CA 19-9 elevation in pulmonary nontuberculous mycobacterial disease. The serum CA 19-9 levels showed a tendency to decrease during successful treatment of pulmonary nontuberculous mycobacterial disease but not in pulmonary tuberculosis. These findings suggest that CA 19-9 may be a useful marker for monitoring therapeutic responses in pulmonary nontuberculous mycobacterial disease, although it is not pulmonary nontuberculous mycobacterial disease-specific marker.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강영애(Kang, Young Ae) ORCID logo https://orcid.org/0000-0002-7783-5271
김세규(Kim, Se Kyu)
김송이(Kim, Song Yee) ORCID logo https://orcid.org/0000-0001-8627-486X
김영삼(Kim, Young Sam) ORCID logo https://orcid.org/0000-0001-9656-8482
박무석(Park, Moo Suk) ORCID logo https://orcid.org/0000-0003-0820-7615
송주한(Song, Joo Han)
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
정경수(Jung, Kyung Soo) ORCID logo https://orcid.org/0000-0003-1604-8730
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