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Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites

Authors
 Seung-Tae Lee  ;  Joseph L. Wiemels 
Citation
 NUCLEIC ACIDS RESEARCH, Vol.44(3) : 1105-1117, 2016 
Journal Title
 NUCLEIC ACIDS RESEARCH 
ISSN
 0305-1048 
Issue Date
2016
MeSH
CpG Islands* ; DNA Copy Number Variations ; DNA Methylation* ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Genome, Human* ; Humans ; Mutation ; Neoplasms/genetics* ; Neoplasms/pathology ; Tumor Cells, Cultured
Abstract
The epigenetic landscape of cancer includes both focal hypermethylation and broader hypomethylation in a genome-wide manner. By means of a comprehensive genomic analysis on 6637 tissues of 21 tumor types, we here show that the degrees of overall methylation in CpG island (CGI) and demethylation in intergenic regions, defined as 'backbone', largely vary among different tumors. Depending on tumor type, both CGI methylation and backbone demethylation are often associated with clinical, epidemiological and biological features such as age, sex, smoking history, anatomic location, histological type and grade, stage, molecular subtype and biological pathways. We found connections between CGI methylation and hypermutability, microsatellite instability, IDH1 mutation, 19p gain and polycomb features, and backbone demethylation with chromosomal instability, NSD1 and TP53 mutations, 5q and 19p loss and long repressive domains. These broad epigenetic patterns add a new dimension to our understanding of tumor biology and its clinical implications.
Files in This Item:
T201601218.pdf Download
DOI
10.1093/nar/gkv1038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146737
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