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Cited 18 times in

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites

DC FieldValueLanguage
dc.contributor.author이승태-
dc.date.accessioned2017-02-24T11:20:12Z-
dc.date.available2017-02-24T11:20:12Z-
dc.date.issued2016-
dc.identifier.issn0305-1048-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146737-
dc.description.abstractThe epigenetic landscape of cancer includes both focal hypermethylation and broader hypomethylation in a genome-wide manner. By means of a comprehensive genomic analysis on 6637 tissues of 21 tumor types, we here show that the degrees of overall methylation in CpG island (CGI) and demethylation in intergenic regions, defined as 'backbone', largely vary among different tumors. Depending on tumor type, both CGI methylation and backbone demethylation are often associated with clinical, epidemiological and biological features such as age, sex, smoking history, anatomic location, histological type and grade, stage, molecular subtype and biological pathways. We found connections between CGI methylation and hypermutability, microsatellite instability, IDH1 mutation, 19p gain and polycomb features, and backbone demethylation with chromosomal instability, NSD1 and TP53 mutations, 5q and 19p loss and long repressive domains. These broad epigenetic patterns add a new dimension to our understanding of tumor biology and its clinical implications.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1105~1117-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNUCLEIC ACIDS RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCpG Islands*-
dc.subject.MESHDNA Copy Number Variations-
dc.subject.MESHDNA Methylation*-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGenome, Human*-
dc.subject.MESHHumans-
dc.subject.MESHMutation-
dc.subject.MESHNeoplasms/genetics*-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHTumor Cells, Cultured-
dc.titleGenome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorJoseph L. Wiemels-
dc.identifier.doi10.1093/nar/gkv1038-
dc.contributor.localIdA04627-
dc.relation.journalcodeJ02387-
dc.identifier.eissn1362-4962-
dc.identifier.pmid26464434-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.citation.volume44-
dc.citation.number3-
dc.citation.startPage1105-
dc.citation.endPage1117-
dc.identifier.bibliographicCitationNUCLEIC ACIDS RESEARCH, Vol.44(3) : 1105-1117, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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