Cited 0 times in
Molecular Imaging of CD44-Overexpressing Gastric Cancer in Mice Using T2 MR Imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 손혜영 | - |
dc.contributor.author | 양재문 | - |
dc.date.accessioned | 2017-02-24T11:17:52Z | - |
dc.date.available | 2017-02-24T11:17:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146724 | - |
dc.description.abstract | Novel diagnostic techniques have been developed in many research area using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. For cancer diagnosis, the use of MRI with biocompatible targeting moieties and manganese ferrite nanoparticles (MFNPs) is preferred. Thus, we synthesized MFNPs using a thermal decomposition method which enables sensitive T2 or T2 Turbo Spin Echo (TSE) MRI and coated them with hyaluronic acid (HA). The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. We also prepared the gastric cancer mice model using MKN-45 cells which has the stem-like property was implanted into BALB/c nude mice. And then HA-MFNPs of the T2 contrast enhancement effects and targeting ability were investigated by in vivo MR imaging. As a result of these studies, we conclude that HA coated MFNPs can be effectively used as a novel probes for visualizing gastric cancer stem cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 196~202 | - |
dc.language | English | - |
dc.publisher | American Scientific Publishers | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Contrast Media*/chemistry | - |
dc.subject.MESH | Contrast Media*/pharmacology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ferric Compounds*/chemistry | - |
dc.subject.MESH | Ferric Compounds*/pharmacology | - |
dc.subject.MESH | Hyaluronan Receptors/biosynthesis* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Manganese Compounds*/chemistry | - |
dc.subject.MESH | Manganese Compounds*/pharmacology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Molecular Imaging/methods* | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Neoplasm Proteins/biosynthesis* | - |
dc.subject.MESH | Neoplasms, Experimental*/diagnostic imaging | - |
dc.subject.MESH | Neoplasms, Experimental*/metabolism | - |
dc.subject.MESH | Radiography | - |
dc.subject.MESH | Stomach Neoplasms*/diagnostic imaging | - |
dc.subject.MESH | Stomach Neoplasms*/metabolism | - |
dc.title | Molecular Imaging of CD44-Overexpressing Gastric Cancer in Mice Using T2 MR Imaging | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Hwunjae Lee | - |
dc.contributor.googleauthor | Seung-Hyun Yang | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Heyoung Son | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04589 | - |
dc.contributor.localId | A02315 | - |
dc.relation.journalcode | J01615 | - |
dc.identifier.eissn | 1533-4899 | - |
dc.identifier.pmid | 27398445 | - |
dc.subject.keyword | Contrast Agent | - |
dc.subject.keyword | Gastric Cancer | - |
dc.subject.keyword | CD44 | - |
dc.subject.keyword | Magnetic Nanoparticles | - |
dc.subject.keyword | Magnetic Resonance Imaging | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.alternativeName | Son, Hye Yeong | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Son, Hye Yeong | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 196 | - |
dc.citation.endPage | 202 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol.16(1) : 196-202, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47467 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.