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Combined effect of individual and neighborhood socioeconomic status on mortality in patients with newly diagnosed dyslipidemia: A nationwide Korean cohort study from 2002-2013

 J. Shin  ;  K.H. Cho  ;  Y. Choi  ;  S.G. Lee  ;  E.-C. Park  ;  S.-I. Jang 
 Nutrition Metabolism and Cardiovascular Diseases, Vol.26(3) : 207-215, 2016 
Journal Title
 Nutrition Metabolism and Cardiovascular Diseases 
Issue Date
Adult ; Aged ; Asian Continental Ancestry Group* ; Dyslipidemias/diagnosis* ; Dyslipidemias/mortality* ; Female ; Humans ; Male ; Middle Aged ; National Health Programs ; Proportional Hazards Models ; Republic of Korea/epidemiology ; Residence Characteristics ; Risk Factors ; Socioeconomic Factors* ; Survival Analysis ; Young Adult
Dyslipidemia ; Hypercholesterolemia ; Hypertriglyceridemia ; Mortality ; Neighborhood ; Socioeconomic status
Background and Aim: The study aims to determine whether dyslipidemia patients living in less affluent neighborhood are at a higher risk of mortality compared to those living in more affluent neighborhoods. Methods and results: A population-based cohort study was conducted using a stratified representative sampling from the National Health Insurance claim data from 2002 to 2013. The target subjects comprise patients newly diagnosed with dyslipidemia receiving medication. We performed a survival analysis using the Cox proportional hazard model. Of 11,946 patients with dyslipidemia, 1053 (8.8%) subjects died during the follow-up period. Of the dyslipidemia patients earning a middle-class income, the adjusted HR in less affluent neighborhoods was higher than that in the more affluent neighborhoods compared to the reference category of high individual SES in more affluent neighborhoods (less affluent; hazard ratio (HR) = 1.64, 95% confidence interval (CI): 1.35–1.99 vs. more affluent; HR = 1.48, 95% CI: 1.20–1.81, respectively). We obtained consistent results in patients with lower income, wherein the adjusted HR in less affluent neighborhoods was higher than that in more affluent neighborhoods (less affluent; HR = 1.52, 95% CI: 1.16–1.97 vs. more affluent; HR = 1.41, 95% CI: 1.04–1.92, respectively). Conclusion: Living in a less affluent neighborhood contributes to higher mortality among dyslipidemia patients. The individual- and neighborhood-level variables cumulatively affect individuals such that the most at-risk individuals include those having both individual- and neighborhood-level risk factors. These findings raise important clinical and public health concerns and indicate that neighborhood SES approaches should be essentially considered in health-care policies similar to individual SES.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
박은철(Park, Eun-Cheol) ORCID logo https://orcid.org/0000-0002-2306-5398
신재용(Shin, Jae Yong)
이상규(Lee, Sang Gyu) ORCID logo https://orcid.org/0000-0003-4847-2421
장성인(Jang, Sung In) ORCID logo https://orcid.org/0000-0002-0760-2878
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