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Small-Scale Fabrication of Biomimetic Structures for Periodontal Regeneration.

DC Field Value Language
dc.contributor.author그린 데이비드-
dc.contributor.author이중석-
dc.contributor.author정한성-
dc.date.accessioned2017-02-24T11:07:11Z-
dc.date.available2017-02-24T11:07:11Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146652-
dc.description.abstractThe periodontium is the supporting tissues for the tooth organ and is vulnerable to destruction, arising from overpopulating pathogenic bacteria and spirochaetes. The presence of microbes together with host responses can destroy large parts of the periodontium sometimes leading tooth loss. Permanent tissue replacements are made possible with tissue engineering techniques. However, existing periodontal biomaterials cannot promote proper tissue architectures, necessary tissue volumes within the periodontal pocket and a "water-tight" barrier, to become clinically acceptable. New kinds of small-scale engineered biomaterials, with increasing biological complexity are needed to guide proper biomimetic regeneration of periodontal tissues. So the ability to make compound structures with small modules, filled with tissue components, is a promising design strategy for simulating the anatomical complexity of the periodotium attachment complexes along the tooth root and the abutment with the tooth collar. Anatomical structures such as, intima, adventitia, and special compartments such as the epithelial cell rests of Malassez or a stellate reticulum niche need to be engineered from the start of regeneration to produce proper periodontium replacement. It is our contention that the positioning of tissue components at the origin is also necessary to promote self-organizing cell-cell connections, cell-matrix connections. This leads to accelerated, synchronized and well-formed tissue architectures and anatomies. This strategy is a highly effective preparation for tackling periodontitis, periodontium tissue resorption, and to ultimately prevent tooth loss. Furthermore, such biomimetic tissue replacements will tackle problems associated with dental implant support and perimimplantitis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent6-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN PHYSIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSmall-Scale Fabrication of Biomimetic Structures for Periodontal Regeneration.-
dc.typeArticle-
dc.publisher.locationSwitzerland-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDep. of Oral Biology, Oral Science Research Center-
dc.contributor.googleauthorDavid W. Green-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorHan-Sung Jung-
dc.identifier.doi10.3389/fphys.2016.00006-
dc.contributor.localIdA04743-
dc.contributor.localIdA03185-
dc.contributor.localIdA03758-
dc.relation.journalcodeJ02868-
dc.identifier.eissn1664-042X-
dc.identifier.pmid26903872-
dc.subject.keyword3D bioprinting-
dc.subject.keywordcell sheet engineering-
dc.subject.keywordmodular biomaterials-
dc.subject.keywordperiodontium-
dc.subject.keywordtissue engineering-
dc.contributor.alternativeNameGreen, David W.-
dc.contributor.alternativeNameLee, Jung Seok-
dc.contributor.alternativeNameJung, Han Sung-
dc.contributor.affiliatedAuthorDavid, William Green-
dc.contributor.affiliatedAuthorLee, Jung Seok-
dc.contributor.affiliatedAuthorJung, Han Sung-
dc.citation.volume7-
dc.citation.startPage6-
dc.identifier.bibliographicCitationFRONTIERS IN PHYSIOLOGY, Vol.7 : 6, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47398-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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