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Serum uric acid concentration and metabolic syndrome among elderly Koreans: The Korean Urban Rural Elderly (KURE) study

Authors
 Hansol Choi  ;  Hyeon Chang Kim  ;  Bo Mi Song  ;  Ji Hye Park  ;  Ju-Mi Lee  ;  Da-Lim Yoon  ;  Young Mi Yoon  ;  Yumie Rhee  ;  Yousik Youm  ;  Chang Oh Kim 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.64 : 51-58, 2016 
Journal Title
 ARCHIVES OF GERONTOLOGY AND GERIATRICS 
ISSN
 0167-4943 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/statistics & numerical data* ; Biomarkers/blood ; Body Mass Index ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Hyperuricemia/blood* ; Hyperuricemia/ethnology ; Logistic Models ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/ethnology ; Multivariate Analysis ; Odds Ratio ; Prevalence ; Risk Factors ; Surveys and Questionnaires ; Uric Acid/blood*
Keywords
Elderly ; Metabolic abnormality ; Metabolic syndrome ; Uric acid
Abstract
BACKGROUND: Epidemiologic studies have demonstrated that elevated serum uric acid concentration is an independent risk factor for metabolic syndrome. However, few studies have focused on elderly populations. Thus, we investigated the association of serum uric acid concentration with metabolic syndrome in community-dwelling elderly Koreans. METHODS: This cross-sectional analysis included 2940 participants (986 men and 1954 women) aged 65 years or older who participated in a baseline health assessment for the Korean Urban Rural Elderly cohort study from 2012 to 2014. Serum uric acid concentration was analyzed using both continuous and dichotomous variables. Hyperuricemia was defined as a uric acid concentration ≥7.0 mg/dL in men and ≥6.0 mg/dL in women. Metabolic syndrome was defined according to the 2009 harmonizing definition. Multiple logistic regression models were used to investigate independent association between serum uric acid and metabolic syndrome, after adjusting for age, body mass index, LDL cholesterol, glycated hemoglobin, blood urea nitrogen, estimated glomerular filtration rate health behaviors, and medications. RESULTS: Prevalence of metabolic syndrome and its components increased significantly according to uric acid concentration in both sexes. The adjusted odds ratios for having metabolic syndrome per 1.0mg/dL higher uric acid concentration were 1.16 (95% CI: 1.03-1.31) in men and 1.27 (95% CI: 1.13-1.42) in women. Hyperuricemia was also associated with metabolic syndrome, with adjusted odds ratios of 1.71 (95% CI: 1.11-2.63) in men and 1.55 (95% CI: 1.05-2.29) in women. CONCLUSIONS: Elevated serum uric acid concentration was independently associated with an increased prevalence of metabolic syndrome in community-dwelling elderly Koreans.
Full Text
http://www.sciencedirect.com/science/article/pii/S016749431630005X
DOI
10.1016/j.archger.2016.01.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Yoon, Da Lim(윤다림)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146622
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