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Chronic Kidney Disease and Functional Outcomes 6 Months after Ischemic Stroke: A Prospective Multicenter Study

 Jang S.Y.  ;  Sohn M.K.  ;  Lee J.  ;  Kim D.Y.  ;  Lee S.-G.  ;  Shin Y.-I.  ;  Oh G.-J.  ;  Lee Y.-S.  ;  Joo M.C.  ;  Han E.Y.  ;  Chang W.H.  ;  Lee A.  ;  Kim J.H.  ;  Kim Y.-H. 
 Neuroepidemiology, Vol.46(1) : 24-30, 2016 
Journal Title
Issue Date
Activities of Daily Living* ; Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/rehabilitation* ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Recovery of Function/physiology* ; Renal Insufficiency, Chronic/complications* ; Sex Factors ; Smoking ; Stroke/complications ; Stroke Rehabilitation* ; Treatment Outcome ; Young Adult
Ischemic stroke ; Functional independence measure ; Korean version of the modified Barthel Index ; Chronic kidney disease
BACKGROUND: The aim of this study was to investigate whether chronic kidney disease (CKD) predicts the outcome of the Functional Independence Measure (FIM) and the Korean version of the modified Barthel Index (K-MBI) 6 months after stroke with adjustment for age, gender, education, smoking, drinking, obesity, hypertension, diabetes mellitus, dyslipidemia, the FIM or K-MBI at discharge and the National Institutes of Health Stroke Scale (NIHSS) score 7 days post stroke. METHODS: This study is an interim report of the Korean Stroke Cohort for Functioning and Rehabilitation. The sample included 2,037 ischemic stroke patients aged 18 years or older. The FIM and K-MBI scores were assessed at discharge and at 6 months after the onset of stroke. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CKD was defined as an eGFR <60 ml/min/1.73 m2. RESULTS: Overall, the mean age was 65.5 (±12.4) years. The proportion of men was 62.6%. The proportion of CKD cases was 12.7%. The means of the 6-month FIM and K-MBI were 109.8 (±27.9) and 87.0 (±26.4), respectively. In multiple linear regressions, the 6-month FIM after stroke was significantly associated with CKD (-2.85, p < 0.05), age (-0.29, p < 0.01), the FIM at discharge (0.46, p < 0.01) and the 7-day NIHSS score (-1.71, p < 0.01). Additionally, the post-stroke 6-month K-MBI was significantly associated with CKD (-2.88, p < 0.01), age (-0.27, p < 0.01), the K-MBI at discharge (0.46, p < 0.01) and the 7-day NIHSS score (-1.55, p < 0.01). CONCLUSIONS: This nationwide hospital-based cohort study showed that CKD might predict poor 6-month FIM and K-MBI scores in ischemic stroke patients.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
김덕용(Kim, Deog Young) ORCID logo https://orcid.org/0000-0001-7622-6311
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