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Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis

Authors
 Chul Hyoung Lyoo  ;  Hanna Cho  ;  Jae Yong Choi  ;  Mi Song Hwang  ;  Sang Kyoon Hong  ;  Yun Joong Kim  ;  Young Hoon Ryu  ;  Myung Sik Lee 
Citation
 Journal of Alzheimers Disease, Vol.51(3) : 671-675, 2016 
Journal Title
 Journal of Alzheimers Disease 
ISSN
 1387-2877 
Issue Date
2016
MeSH
Adult ; Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology* ; Aniline Compounds ; Brain Mapping ; Carbolines ; Female ; Humans ; Male ; Motor Cortex/diagnostic imaging ; Motor Cortex/metabolism* ; Motor Cortex/pathology ; Mutation, Missense ; Paraparesis, Spastic/diagnostic imaging ; Paraparesis, Spastic/genetics ; Paraparesis, Spastic/pathology ; Paraparesis, Spastic/physiopathology* ; Positron-Emission Tomography ; Presenilin-1/genetics ; Radiopharmaceuticals ; Stilbenes ; tau Proteins/metabolism*
Keywords
Alzheimer’s disease ; PET ; amyloid ; spastic paraplegia ; tau protein
Abstract
We studied topographic distribution of tau and amyloid-β in a patient with variant Alzheimer's disease with spastic paraparesis (VarAD) by comparing AD patients. The proband developed progressive memory impairment, dysarthria, and spastic paraparesis at age 23. Heterozygous missense mutation (L166P) was found in exon 6 of presenilin-1 gene. The proband showed prominently increased amyloid binding in striatum and cerebellum and asymmetrical tau binding in the primary sensorimotor cortex contralateral to the side more affected by spasticity. We suspect that upper motor neuron dysfunctions may be attributed to excessive abnormal tau accumulation rather than amyloid-β in the primary motor cortex.
Full Text
http://content.iospress.com/articles/journal-of-alzheimers-disease/jad151052
DOI
10.3233/JAD-151052
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
유영훈(Ryu, Young Hoon)
이명식(Lee, Myung Sik)
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146592
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