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Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction

Authors
 Aran Son  ;  Seonghee Park  ;  Dong Min Shin  ;  Shmuel Muallem 
Citation
 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Vol.310(6) : 414-422, 2016 
Journal Title
 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 
ISSN
 0363-6143 
Issue Date
2016
MeSH
Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Cell Membrane/metabolism* ; Endoplasmic Reticulum/metabolism* ; Membrane Proteins/metabolism* ; Pancreas/metabolism*
Keywords
ER ; PM ; junctions ; pancreas ; signaling
Abstract
Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca(2+) signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca(2+) signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca(2+) release and Orai1/transient receptor potential canonical-mediated store-dependent Ca(2+) entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca(2+) signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca(2+) signaling in pancreatic acini.
Full Text
http://ajpcell.physiology.org/content/310/6/C414
DOI
10.1152/ajpcell.00349.2015
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Min(신동민) ORCID logo https://orcid.org/0000-0001-6042-0435
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146571
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