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The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: a randomised controlled study

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김만득-
dc.contributor.author김소연-
dc.contributor.author반민지-
dc.contributor.author신증수-
dc.date.accessioned2017-02-24T08:09:59Z-
dc.date.available2017-02-24T08:09:59Z-
dc.date.issued2016-
dc.identifier.issn1470-0328-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146570-
dc.description.abstractOBJECTIVE: To investigate the effects of single-dose intravenous dexamethasone on inflammatory responses, pain, nausea, and vomiting after uterine artery embolisation (UAE). DESIGN: Prospective, randomised, double-blind, and placebo-controlled study. SETTING: Tertiary-care University centre in Korea. POPULATION: Patients undergoing UAE for the treatment of symptomatic fibroids or adenomyosis. METHODS: Patients were randomised to receive either intravenous dexamethasone (10 mg; dexamethasone group) or normal saline (control group) 1 hour before UAE. Both groups received fentanyl-based intravenous patient-controlled analgesia (PCA) during the 24 hours after UAE. MAIN OUTCOME MEASURES: The primary outcomes were the inflammatory and stress responses measured by white blood cell count, neutrophil percentage, C-reactive protein (CRP), interleukin-6 (IL-6), and cortisol. Secondary outcomes were severity of pain and incidence of nausea and vomiting. RESULTS: Sixty-four patients were enrolled and 59 patients completed the study. CRP, IL-6, and cortisol were significantly lower in the dexamethasone group compared with the control group during the 24 hours after UAE. Although the cumulative dose of fentanyl and additional analgesics administered during the 24 hours after UAE were similar between the two groups, pain scores were significantly lower in the dexamethasone group from 12 hours after UAE, and the incidence of severe nausea and vomiting was lower in the dexamethasone group. CONCLUSIONS: The administration of single-dose intravenous dexamethasone as an adjunct to fentanyl-based intravenous PCA is effective in reducing inflammation and pain during the first 24 hours after UAE. TWEETABLE ABSTRACT: Dexamethasone is effective in reducing inflammation and pain after uterine artery embolisation.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent580~587-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfBJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenomyosis/epidemiology-
dc.subject.MESHAdenomyosis/therapy*-
dc.subject.MESHAdult-
dc.subject.MESHAnalgesics/administration & dosage*-
dc.subject.MESHAnti-Inflammatory Agents/administration & dosage*-
dc.subject.MESHDexamethasone/administration & dosage*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLeiomyoma/epidemiology-
dc.subject.MESHLeiomyoma/therapy*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHPostoperative Nausea and Vomiting/drug therapy*-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUterine Artery Embolization/adverse effects*-
dc.subject.MESHUterine Neoplasms/epidemiology-
dc.subject.MESHUterine Neoplasms/therapy*-
dc.titleThe effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: a randomised controlled study-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorSY Kim-
dc.contributor.googleauthorB-N Koo-
dc.contributor.googleauthorCS Shin-
dc.contributor.googleauthorM Ban-
dc.contributor.googleauthorK Han-
dc.contributor.googleauthorMD Kim-
dc.identifier.doi10.1111/1471-0528.13785-
dc.contributor.localIdA00193-
dc.contributor.localIdA00420-
dc.contributor.localIdA00616-
dc.contributor.localIdA04577-
dc.contributor.localIdA02159-
dc.relation.journalcodeJ00339-
dc.identifier.eissn1471-0528-
dc.relation.journalsince2000~-
dc.identifier.pmid26667403-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13785/abstract-
dc.subject.keywordDexamethasone-
dc.subject.keywordinflammation-
dc.subject.keywordnausea-
dc.subject.keywordpain-
dc.subject.keyworduterine artery embolisation-
dc.subject.keywordvomiting-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, Man Deuk-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameBan, Min Gi-
dc.contributor.alternativeNameShin, Cheung Soo-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, Man Deuk-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorBan, Min Gi-
dc.contributor.affiliatedAuthorShin, Cheung Soo-
dc.citation.volume123-
dc.citation.number4-
dc.citation.startPage580-
dc.citation.endPage587-
dc.identifier.bibliographicCitationBJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol.123(4) : 580-587, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid46379-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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