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The antibacterial effect of xanthorrhizol as an endodontic irrigant on Enterococcus faecalis

 Wonyoung Yue  ;  Minju Song  ;  Si-Mook Kang  ;  Baek-il Kim  ;  Tai-Cheol Yoon  ;  Euiseong Kim 
 Journal of the Korean Dental Association (대한치과의사협회지), Vol.54(3) : 206-216, 2016 
Journal Title
Journal of the Korean Dental Association(대한치과의사협회지)
Issue Date
Xanthorrhizol ; chlorhexidine ; root canal irrigation ; E. faecalis
Objectives: The aim of this study was to evaluate the antibacterial effect of xanthorrhizol (XTZ) on E. faecalis, compared with 2% chlorhexidine (CHX).
Materials and Methods: Normal physiological state (NS), starvation state (SS), and alkalization state (AS) of E. faecalis were used. A solution containing 1% XTZ in 30% ethanol, 1% dimethyl sulfoxide (DMSO), and 100 mg/ml sodium methyl cocoyl taurate was used and is referred to as Xan in this study. To determine the minimal bactericidal concentration (MBC) of Xan and CHX, 500μl of E. faecalis (NS and two stress states) was added to a microtube containing 500μl of serial 2-fold dilutions of 1% Xan and 2% CHX (1:2-1:128). The MBC of each antimicrobial was determined by the plate count method.
Results: The antibacterial effect of Xan was more effective on E. faecalis in AS than in the other states (NS, SS) at 0.125% Xan and 0.03325% Xan (P<0.05). In contrast, the antibacterial effect of CHX was more effective against E. faecalis in SS than the other states (NS, AS) at 0.0625% CHX (P<0.05). In SS, the antibacterial effect of CHX was more effective than that of Xan at 0.125% and 0.0625% (P<0.05). However, in AS, the antibacterial effect of Xan was more effective than that of CHX at 0.0625% and 0.03325% (P<0.05).
Conclusions: In endodontic retreatment cases in which it is important to effectively remove E. faecalis from the infected root canal, Xan may be more suitable when combined with NaOCl than CHX.
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2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kang, Si-Mook(강시묵) ORCID logo https://orcid.org/0000-0003-2341-3636
Kim, Baek Il(김백일) ORCID logo https://orcid.org/0000-0001-8234-2327
Kim, Eui Seong(김의성) ORCID logo https://orcid.org/0000-0003-2126-4761
Song, Min Ju(송민주)
Yue, Won Young(유원영)
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