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Identification of a Peptidergic Pathway Critical to Satiety Responses in Drosophila

Authors
 Soohong Min  ;  Hyo-Seok Chae  ;  Yong-Hoon Jang  ;  Sekyu Choi  ;  Sion Lee  ;  Yong Taek Jeong  ;  Walton D. Jones  ;  Seok Jun Moon  ;  Young-Joon Kim  ;  Jongkyeong Chung 
Citation
 CURRENT BIOLOGY, Vol.26 : 814-820, 2016 
Journal Title
 CURRENT BIOLOGY 
ISSN
 0960-9822 
Issue Date
2016
MeSH
Animals ; Animals, Genetically Modified ; Body Weight ; Brain/physiology ; Drosophila/physiology* ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism* ; Eating ; Feeding Behavior ; Female ; Gene Expression Regulation ; Male ; Neurons/metabolism ; Peptides/metabolism ; Receptors, Peptide ; Satiety Response/physiology* ; TRPA1 Cation Channel ; TRPC Cation Channels/metabolism
Abstract
Although several neural pathways have been implicated in feeding behaviors in mammals [1-7], it remains unclear how the brain coordinates feeding motivations to maintain a constant body weight (BW). Here, we identified a neuropeptide pathway important for the satiety and BW control in Drosophila. Silencing of myoinhibitory peptide (MIP) neurons significantly increased BW through augmented food intake and fat storage. Likewise, the loss-of-function mutation of mip also increased feeding and BW. Suppressing the MIP pathway induced satiated flies to behave like starved ones, with elevated sensitivity toward food. Conversely, activating MIP neurons greatly decreased food intake and BW and markedly blunted the sensitivity of starved flies toward food. Upon terminating the activation protocol of MIP neurons, the decreased BW reverts rapidly to the normal level through a strong feeding rebound, indicating the switch-like role of MIP pathway in feeding. Surprisingly, the MIP-mediated BW decrease occurred independently of sex peptide receptor (SPR), the only known receptor for MIP, suggesting the presence of a yet-unknown MIP receptor. Together, our results reveal a novel anorexigenic pathway that controls satiety in Drosophila and provide a new avenue to study how the brain actively maintains a constant BW.
Full Text
http://www.sciencedirect.com/science/article/pii/S0960982216000798
DOI
10.1016/j.cub.2016.01.029
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Jeong, Yong Taek(정용택) ORCID logo https://orcid.org/0000-0003-0067-6396
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146485
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