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Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study

 Dong-Hyuk Jung  ;  Yong-Jae Lee  ;  Chun-Bae Kim  ;  Jang-Young Kim  ;  Seung-Hun Shin  ;  Jong-Ku Park 
 Complementary Therapies in Medicine, Vol.24 : 40-46, 2016 
Journal Title
 Complementary Therapies in Medicine 
Issue Date
Adult ; Biomarkers/blood ; DNA, Mitochondrial/drug effects* ; Gene Dosage/drug effects* ; Hormones/blood ; Humans ; Inflammation ; Leukocytes, Mononuclear/drug effects* ; Male ; Metabolic Syndrome/drug therapy* ; Middle Aged ; Panax/chemistry* ; Pilot Projects ; Plant Extracts/pharmacology*
Ginseng ; Metabolic syndrome ; Mitochondrial function
BACKGROUND: It has been observed that mitochondrial dysfunction is associated with an increased risk of metabolic syndrome. There is growing evidence that hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis and hormone (testosterone and growth hormone) deficiency may lead to metabolic syndrome. Recent studies have reported that ginseng treatment improves mitochondrial and HPA-axis function and increases anabolic hormone secretion. OBJECTIVES: The objective of this study was to investigate the effect of red ginseng (RG) on metabolic syndrome, hormones, and mitochondrial function using leukocyte mitochondrial DNA copy number in men with metabolic syndrome. METHODS: We performed a randomized, double-blind, placebo-controlled study in 62 subjects who were not taking drugs that could affect their metabolic function. A total of 62 men with metabolic syndrome were randomly assigned to either an RG group (3.0g/day) or a placebo group for 4 weeks. We analyzed changes in metabolic syndrome components, leukocyte mitochondrial DNA copy number, hormones (total testosterone, IGF-1, cortisol, and DHEAS) and inflammatory markers (C-reactive protein, ferritin) from baseline to 4 weeks. RESULTS: Significant improvement in mitochondrial function (95% CI -44.9 to -1.3) and an increase in total testosterone (95% CI -70.1 to -1.0) and IGF-1(P=0.01) levels were observed in the RG group when compared with the placebo group. Diastolic blood pressure (95% CI 2.0-9.4) and serum cortisol (95% CI 1.1-5.5) significantly decreased in the RG group. CONCLUSIONS: We found evidence that RG had a favorable effect on mitochondrial function and hormones in men with metabolic syndrome. TRIAL REGISTRATION: ClinicalTrials.gov NCT02034136.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
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