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Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease

DC FieldValueLanguage
dc.contributor.author김경원-
dc.contributor.author김명준-
dc.contributor.author김상겸-
dc.contributor.author김세훈-
dc.contributor.author김윤희-
dc.contributor.author심효섭-
dc.contributor.author이미정-
dc.contributor.author손명현-
dc.contributor.author김규언-
dc.contributor.author이창영-
dc.date.accessioned2017-02-24T07:36:46Z-
dc.date.available2017-02-24T07:36:46Z-
dc.date.issued2016-
dc.identifier.issn8755-6863-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146467-
dc.description.abstractBACKGROUND: Humidifier disinfectant-associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality. OBJECTIVES: To evaluate the differences in clinical findings between survivors and non-survivors of humidifier disinfectant-associated children's interstitial lung disease. To evaluate dynamic changes in serum cytokines related to inflammation and fibrosis in lung injury, and to determine whether these changes are predictive of survival in this disease. METHODS: We evaluated 17 children with humidifier disinfectant-associated children's interstitial lung disease, from whom serum samples were obtained weekly during hospitalization. The severity of chest tomographic and lung pathologic findings was scored. Levels of several cytokines were measured in the serial serum samples. RESULTS: Seven of the 17 children were survivors. Compared to survivors, non-survivors had greater ground-glass attenuation on follow-up chest tomography, higher admission neutrophil counts, and more macrophages on pathologic findings. Transforming growth factor-beta 1 persisted at an elevated level (1,000-1,500 pg/ml) in survivors, whereas it decreased abruptly in non-survivors. At the time of this decrease, non-survivors had clinical worsening of their respiratory failure. Transforming growth factor-beta 1 was positively correlated with PaO2 /FiO2 (r = 0.481, P < 0.0001). CONCLUSIONS: Non-survivors exhibited more inflammatory clinical findings than survivors. Transforming growth factor-beta 1 remained elevated in survivors, suggesting that it affected the clinical course of humidifier disinfectant-associated children's interstitial lung disease. The prognosis of this lung disease may depend more on controlling excessive inflammation and repairing damaged lung than on fibrosis, and transforming growth factor-beta 1 may play a key role in this process.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent173~182-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfPEDIATRIC PULMONOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Adhesion Molecules/immunology-
dc.subject.MESHChemokine CCL2/immunology-
dc.subject.MESHChemokine CCL5/immunology-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDisinfectants/adverse effects*-
dc.subject.MESHFemale-
dc.subject.MESHFibrosis-
dc.subject.MESHGranulocyte-Macrophage Colony-Stimulating Factor/immunology-
dc.subject.MESHHumans-
dc.subject.MESHHumidifiers*-
dc.subject.MESHInfant-
dc.subject.MESHInflammation-
dc.subject.MESHInterleukin-13/immunology-
dc.subject.MESHInterleukin-8/immunology-
dc.subject.MESHLung/diagnostic imaging-
dc.subject.MESHLung/immunology*-
dc.subject.MESHLung/pathology-
dc.subject.MESHLung Diseases, Interstitial/chemically induced-
dc.subject.MESHLung Diseases, Interstitial/immunology*-
dc.subject.MESHLung Diseases, Interstitial/mortality-
dc.subject.MESHLung Injury/chemically induced-
dc.subject.MESHLung Injury/immunology*-
dc.subject.MESHLung Injury/mortality-
dc.subject.MESHMale-
dc.subject.MESHMatrix Metalloproteinase 9/immunology-
dc.subject.MESHPrognosis-
dc.subject.MESHTomography, X-Ray Computed-
dc.subject.MESHTransforming Growth Factor beta1/immunology*-
dc.subject.MESHVascular Endothelial Growth Factor A/immunology-
dc.titleTransforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorYoon Hee Kim-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorKyung Eun Lee-
dc.contributor.googleauthorMi-Jung Lee-
dc.contributor.googleauthorSang Kyum Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorHyo Sup Shim-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorMyung-Joon Kim-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorKyu-Earn Kim-
dc.identifier.doi10.1002/ppul.23226-
dc.contributor.localIdA00303-
dc.contributor.localIdA00425-
dc.contributor.localIdA00520-
dc.contributor.localIdA00610-
dc.contributor.localIdA00799-
dc.contributor.localIdA02219-
dc.contributor.localIdA02774-
dc.contributor.localIdA01967-
dc.contributor.localIdA00327-
dc.contributor.localIdA03245-
dc.relation.journalcodeJ02491-
dc.identifier.eissn1099-0496-
dc.identifier.pmid26111363-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ppul.23226/abstract-
dc.subject.keywordchild-
dc.subject.keywordinterstitial-
dc.subject.keywordlung disease-
dc.subject.keywordprognosis-
dc.subject.keywordtransforming growth factor beta1-
dc.subject.keywordwound healing-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameKim, Myung Joon-
dc.contributor.alternativeNameKim, Sang Kyum-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Yoon Hee-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorKim, Myung Joon-
dc.contributor.affiliatedAuthorKim, Sang Kyum-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Yoon Hee-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.citation.volume51-
dc.citation.number2-
dc.citation.startPage173-
dc.citation.endPage182-
dc.identifier.bibliographicCitationPEDIATRIC PULMONOLOGY, Vol.51(2) : 173-182, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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