Cited 9 times in
Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김명준 | - |
dc.contributor.author | 김상겸 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김윤희 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 이창영 | - |
dc.date.accessioned | 2017-02-24T07:36:46Z | - |
dc.date.available | 2017-02-24T07:36:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 8755-6863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146467 | - |
dc.description.abstract | BACKGROUND: Humidifier disinfectant-associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality. OBJECTIVES: To evaluate the differences in clinical findings between survivors and non-survivors of humidifier disinfectant-associated children's interstitial lung disease. To evaluate dynamic changes in serum cytokines related to inflammation and fibrosis in lung injury, and to determine whether these changes are predictive of survival in this disease. METHODS: We evaluated 17 children with humidifier disinfectant-associated children's interstitial lung disease, from whom serum samples were obtained weekly during hospitalization. The severity of chest tomographic and lung pathologic findings was scored. Levels of several cytokines were measured in the serial serum samples. RESULTS: Seven of the 17 children were survivors. Compared to survivors, non-survivors had greater ground-glass attenuation on follow-up chest tomography, higher admission neutrophil counts, and more macrophages on pathologic findings. Transforming growth factor-beta 1 persisted at an elevated level (1,000-1,500 pg/ml) in survivors, whereas it decreased abruptly in non-survivors. At the time of this decrease, non-survivors had clinical worsening of their respiratory failure. Transforming growth factor-beta 1 was positively correlated with PaO2 /FiO2 (r = 0.481, P < 0.0001). CONCLUSIONS: Non-survivors exhibited more inflammatory clinical findings than survivors. Transforming growth factor-beta 1 remained elevated in survivors, suggesting that it affected the clinical course of humidifier disinfectant-associated children's interstitial lung disease. The prognosis of this lung disease may depend more on controlling excessive inflammation and repairing damaged lung than on fibrosis, and transforming growth factor-beta 1 may play a key role in this process. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 173~182 | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | PEDIATRIC PULMONOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Adhesion Molecules/immunology | - |
dc.subject.MESH | Chemokine CCL2/immunology | - |
dc.subject.MESH | Chemokine CCL5/immunology | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Disinfectants/adverse effects* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Granulocyte-Macrophage Colony-Stimulating Factor/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Humidifiers* | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Interleukin-13/immunology | - |
dc.subject.MESH | Interleukin-8/immunology | - |
dc.subject.MESH | Lung/diagnostic imaging | - |
dc.subject.MESH | Lung/immunology* | - |
dc.subject.MESH | Lung/pathology | - |
dc.subject.MESH | Lung Diseases, Interstitial/chemically induced | - |
dc.subject.MESH | Lung Diseases, Interstitial/immunology* | - |
dc.subject.MESH | Lung Diseases, Interstitial/mortality | - |
dc.subject.MESH | Lung Injury/chemically induced | - |
dc.subject.MESH | Lung Injury/immunology* | - |
dc.subject.MESH | Lung Injury/mortality | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 9/immunology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Transforming Growth Factor beta1/immunology* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/immunology | - |
dc.title | Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Yoon Hee Kim | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Mi-Jung Lee | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Myung-Joon Kim | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Kyu-Earn Kim | - |
dc.identifier.doi | 10.1002/ppul.23226 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00425 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00799 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A02774 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A03245 | - |
dc.relation.journalcode | J02491 | - |
dc.identifier.eissn | 1099-0496 | - |
dc.identifier.pmid | 26111363 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ppul.23226/abstract | - |
dc.subject.keyword | child | - |
dc.subject.keyword | interstitial | - |
dc.subject.keyword | lung disease | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | transforming growth factor beta1 | - |
dc.subject.keyword | wound healing | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Myung Joon | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Yoon Hee | - |
dc.contributor.alternativeName | Shim, Hyo Sup | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Myung Joon | - |
dc.contributor.affiliatedAuthor | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Hee | - |
dc.contributor.affiliatedAuthor | Shim, Hyo Sup | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.citation.volume | 51 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 182 | - |
dc.identifier.bibliographicCitation | PEDIATRIC PULMONOLOGY, Vol.51(2) : 173-182, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45111 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.