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Intraoperative Dexmedetomidine Improves the Quality of Recovery and Postoperative Pulmonary Function in Patients Undergoing Video-assisted Thoracoscopic Surgery: A CONSORT-Prospective, Randomized, Controlled Trial

Authors
 Su Hyun Lee  ;  Chang Yeong Lee  ;  Jin Gu Lee  ;  Namo Kim  ;  Hye Mi Lee  ;  Young Jun Oh 
Citation
 MEDICINE, Vol.95(7) : 2854, 2016 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2016
MeSH
Adrenergic alpha-2 Receptor Agonists/administration & dosage* ; Aged ; Dexmedetomidine/administration & dosage* ; Female ; Humans ; Intraoperative Care ; Lung/drug effects* ; Male ; Middle Aged ; Prospective Studies ; Recovery of Function/drug effects* ; Thoracic Surgery, Video-Assisted*
Abstract
Video-assistedthoracoscopicsurgery(VATS) has been known to be a stressful event forpatients, anddexmedetomidineis known to attenuatesurgery-induced sympathetic responses and potentiate analgesia in perioperative periods. The present was designed to evaluate the effects ofintraoperativedexmedetomidineadministration on thequalityofrecovery(QoR) andpulmonaryfunctionafter VATS.Patientswith lung cancerundergoingVATS wererandomizedto Dex group (loading of 1.0 μg/kg for 20 minutes before the termination ofsurgery, n = 50) or Control group (comparable volume of normal saline, n = 50). The QoR-40 questionnaire assessespostoperativerecoveryand validates the overall surgical and general anesthesia outcomes. The QoR-40 scores, forced expiratory volume for 1 second (FEV1) onpostoperativeday (POD) 1 and 2, and emergence agitation were evaluated. The global QoR-40 score (162.3 ± 17.8 vs 153.3 ± 18.7, P = 0.016 on POD 1; 174.3 ± 16.0 vs 166.8 ± 16.7, P = 0.028 on POD 2) and FEV1 (2.1 ± 0.4 vs 1.9 ± 0.5 L, P = 0.034 on POD 1; 2.2 ± 0.5 vs 2.0 ± 0.4 L, P = 0.030 on POD 2) were significantly higher in the Dex group compared with the Control group on POD1 and POD 2. The score of emergence agitation was lower in the Dex group compared with the Control group (3 [2-5] vs 5 [3-7], P < 0.001). The number ofpatientsindicating severe emergence agitation was shorter in the Dex group than Control group (0 [0%] vs 7 [14%], P = 0.048). The length of hospital stay was significantly shorter (6.7 [3-9] vs 8.4 [4-9] days, P = 0.045) in the Dex group compared with the Control group.Intraoperativedexmedetomidineadministration improved QoR,postoperativepulmonaryfunction, and emergence agitation inpatientsundergoingVATS. Consequently,intraoperativedexmedetomidineadministration could improvepostoperativeoutcomes and reduced the length of hospital stay inpatientsundergoingVATS.
Files in This Item:
T201600612.pdf Download
DOI
10.1097/MD.0000000000002854
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Namo(김남오) ORCID logo https://orcid.org/0000-0002-0829-490X
Oh, Young Jun(오영준) ORCID logo https://orcid.org/0000-0002-6258-5695
Lee, Su Hyun(이수현)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Lee, Hye Mi(이혜미) ORCID logo https://orcid.org/0000-0002-0432-1878
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146465
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