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Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD

 Su Jin Jeong  ;  Claire Italiano  ;  Romanee Chaiwarith  ;  Oon Tek Ng  ;  Sasheela Vanar  ;  Awachana Jiamsakul  ;  Vonthanak Saphonn  ;  Kinh Van Nguyen  ;  Sasisopin Kiertiburanakul  ;  Man Po Lee  ;  Tuti Parwati Merati  ;  Thuy Thanh Pham  ;  Evy Yunihastuti  ;  Rossana Ditangco  ;  Nagalingeswaran Kumarasamy  ;  Fujie Zhang  ;  Wingwai Wong  ;  Benedict L.H. Sim  ;  Sanjay Pujari  ;  Pacharee Kantipong  ;  Praphan Phanuphak  ;  Winai Ratanasuwan  ;  Shinichi Oka  ;  Mahiran Mustafa  ;  Nicolas Durier  ;  Jun Yong Choi 
 AIDS Research and Human Retroviruses, Vol.32(3) : 255-261, 2016 
Journal Title
 AIDS Research and Human Retroviruses 
Issue Date
Adult ; Age Factors ; Asia/epidemiology ; CD4 Lymphocyte Count ; Delayed Diagnosis* ; Female ; HIV Infections/diagnosis* ; HIV Infections/epidemiology ; HIV Infections/pathology ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Sex Factors ; Sexual Behavior ; Substance Abuse, Intravenous
Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003-2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31-40, 41-50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31-1.88; OR = 2.01, 95% CI 1.58-2.56; and OR = 1.69, 95% CI 1.23-2.31, respectively; all p ≤ 0.001]. Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42-3.27, p < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35-0.58, p < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36-0.53, p < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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