0 799

Cited 19 times in

Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection

DC Field Value Language
dc.contributor.author김종석-
dc.contributor.author신성재-
dc.date.accessioned2017-02-24T07:32:34Z-
dc.date.available2017-02-24T07:32:34Z-
dc.date.issued2016-
dc.identifier.issn0171-2985-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146450-
dc.description.abstractA gradual understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mycobacterium tuberculosis (Mtb) genome, has uncovered unique roles in host-pathogen interactions. However, the immunological function of PE27 (Rv2769c), the largest PE member, remains unclear. Here, we explored the functional roles and related signaling mechanisms of PE27 in the interaction with dendritic cells (DCs) to shape the T cell response. PE27 phenotypically and functionally induces DC maturation by up-regulating CD80, CD86, MHC class I and MHC class II expression on the DC surface to promote the production of TNF-α, IL-1β, IL-6, and IL-12p70 but not IL-10. Additionally, we found that PE27-mediated DC activation requires the participation of mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) signaling pathways. Interestingly, PE27-treated DCs directed naïve CD4(+) T cells to secrete IFN-γ and activate T-bet but not GATA-3. PE27 also induced IFN-γ-producing memory T cell responses in Mtb-infected mice, indicating that PE27 contributes to Th1-polarization. Taken together, these findings suggest that PE27 possesses Th1-polarizing potential through DC maturation and could be useful in the design of TB vaccines.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent440~453-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfIMMUNOBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntigens, Bacterial/immunology*-
dc.subject.MESHCytokines/biosynthesis-
dc.subject.MESHDendritic Cells/immunology*-
dc.subject.MESHDendritic Cells/metabolism-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHImmunologic Memory*-
dc.subject.MESHImmunophenotyping-
dc.subject.MESHLymphocyte Activation/immunology*-
dc.subject.MESHMice-
dc.subject.MESHMitogen-Activated Protein Kinases/metabolism-
dc.subject.MESHMycobacterium tuberculosis/immunology*-
dc.subject.MESHNF-kappa B/metabolism-
dc.subject.MESHPhenotype-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTh1 Cells/immunology*-
dc.subject.MESHTh1 Cells/metabolism-
dc.subject.MESHTuberculosis/immunology*-
dc.subject.MESHTuberculosis/microbiology*-
dc.titleMycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeResearcher Institutes-
dc.contributor.departmentInstitute for Immunology and Immunological Disease-
dc.contributor.googleauthorWoo Sik Kim-
dc.contributor.googleauthorJong-Seok Kim-
dc.contributor.googleauthorSeung Bin Cha-
dc.contributor.googleauthorSo Jeong Kim-
dc.contributor.googleauthorHongmin Kim-
dc.contributor.googleauthorKee Woong Kwon-
dc.contributor.googleauthorSeung Jung Han-
dc.contributor.googleauthorSoo Young Choi-
dc.contributor.googleauthorSung Jae Shin-
dc.identifier.doi10.1016/j.imbio.2015.11.006-
dc.contributor.localIdA00920-
dc.contributor.localIdA02114-
dc.relation.journalcodeJ01035-
dc.identifier.eissn1878-3279-
dc.identifier.pmid26655143-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0171298515300905-
dc.subject.keywordDCs-
dc.subject.keywordDendritic cell-
dc.subject.keywordIFN-γ-
dc.subject.keywordIL-10-
dc.subject.keywordIL-12p70-
dc.subject.keywordIL-1β-
dc.subject.keywordIL-2-
dc.subject.keywordIL-6-
dc.subject.keywordMAPKs-
dc.subject.keywordMaturation-
dc.subject.keywordMtb-
dc.subject.keywordMycobacterium tuberculosis-
dc.subject.keywordNF-κB-
dc.subject.keywordPE-
dc.subject.keywordPE27-
dc.subject.keywordPPE-
dc.subject.keywordTNF-α-
dc.subject.keywordTh1 polarization-
dc.subject.keyworddendritic cells-
dc.subject.keywordinterferon-γ-
dc.subject.keywordinterleukin 10-
dc.subject.keywordinterleukin 12p70-
dc.subject.keywordinterleukin 2-
dc.subject.keywordinterleukin 6-
dc.subject.keywordinterleukin-1β-
dc.subject.keywordmitogen-activated protein kinases-
dc.subject.keywordnuclear factor κB-
dc.subject.keywordproline-glutamate-
dc.subject.keywordproline-proline-glutamate-
dc.subject.keywordtumor necrosis factor-α-
dc.contributor.alternativeNameKim, Jong Seok-
dc.contributor.alternativeNameShin, Sung Jae-
dc.contributor.affiliatedAuthorKim, Jong Seok-
dc.contributor.affiliatedAuthorShin, Sung Jae-
dc.citation.volume221-
dc.citation.number3-
dc.citation.startPage440-
dc.citation.endPage453-
dc.identifier.bibliographicCitationIMMUNOBIOLOGY, Vol.221(3) : 440-453, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid45094-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.