Cited 20 times in
Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종석 | - |
dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2017-02-24T07:32:34Z | - |
dc.date.available | 2017-02-24T07:32:34Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0171-2985 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146450 | - |
dc.description.abstract | A gradual understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mycobacterium tuberculosis (Mtb) genome, has uncovered unique roles in host-pathogen interactions. However, the immunological function of PE27 (Rv2769c), the largest PE member, remains unclear. Here, we explored the functional roles and related signaling mechanisms of PE27 in the interaction with dendritic cells (DCs) to shape the T cell response. PE27 phenotypically and functionally induces DC maturation by up-regulating CD80, CD86, MHC class I and MHC class II expression on the DC surface to promote the production of TNF-α, IL-1β, IL-6, and IL-12p70 but not IL-10. Additionally, we found that PE27-mediated DC activation requires the participation of mitogen-activated protein kinases (MAPKs) and nuclear factor κB (NF-κB) signaling pathways. Interestingly, PE27-treated DCs directed naïve CD4(+) T cells to secrete IFN-γ and activate T-bet but not GATA-3. PE27 also induced IFN-γ-producing memory T cell responses in Mtb-infected mice, indicating that PE27 contributes to Th1-polarization. Taken together, these findings suggest that PE27 possesses Th1-polarizing potential through DC maturation and could be useful in the design of TB vaccines. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 440~453 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | IMMUNOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Bacterial/immunology* | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Dendritic Cells/immunology* | - |
dc.subject.MESH | Dendritic Cells/metabolism | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunologic Memory* | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Lymphocyte Activation/immunology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/metabolism | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Th1 Cells/immunology* | - |
dc.subject.MESH | Th1 Cells/metabolism | - |
dc.subject.MESH | Tuberculosis/immunology* | - |
dc.subject.MESH | Tuberculosis/microbiology* | - |
dc.title | Mycobacterium tuberculosis PE27 activates dendritic cells and contributes to Th1-polarized memory immune responses during in vivo infection | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | Researcher Institutes | - |
dc.contributor.department | Institute for Immunology and Immunological Disease | - |
dc.contributor.googleauthor | Woo Sik Kim | - |
dc.contributor.googleauthor | Jong-Seok Kim | - |
dc.contributor.googleauthor | Seung Bin Cha | - |
dc.contributor.googleauthor | So Jeong Kim | - |
dc.contributor.googleauthor | Hongmin Kim | - |
dc.contributor.googleauthor | Kee Woong Kwon | - |
dc.contributor.googleauthor | Seung Jung Han | - |
dc.contributor.googleauthor | Soo Young Choi | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.identifier.doi | 10.1016/j.imbio.2015.11.006 | - |
dc.contributor.localId | A00920 | - |
dc.contributor.localId | A02114 | - |
dc.relation.journalcode | J01035 | - |
dc.identifier.eissn | 1878-3279 | - |
dc.identifier.pmid | 26655143 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0171298515300905 | - |
dc.subject.keyword | DCs | - |
dc.subject.keyword | Dendritic cell | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | IL-10 | - |
dc.subject.keyword | IL-12p70 | - |
dc.subject.keyword | IL-1β | - |
dc.subject.keyword | IL-2 | - |
dc.subject.keyword | IL-6 | - |
dc.subject.keyword | MAPKs | - |
dc.subject.keyword | Maturation | - |
dc.subject.keyword | Mtb | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | PE | - |
dc.subject.keyword | PE27 | - |
dc.subject.keyword | PPE | - |
dc.subject.keyword | TNF-α | - |
dc.subject.keyword | Th1 polarization | - |
dc.subject.keyword | dendritic cells | - |
dc.subject.keyword | interferon-γ | - |
dc.subject.keyword | interleukin 10 | - |
dc.subject.keyword | interleukin 12p70 | - |
dc.subject.keyword | interleukin 2 | - |
dc.subject.keyword | interleukin 6 | - |
dc.subject.keyword | interleukin-1β | - |
dc.subject.keyword | mitogen-activated protein kinases | - |
dc.subject.keyword | nuclear factor κB | - |
dc.subject.keyword | proline-glutamate | - |
dc.subject.keyword | proline-proline-glutamate | - |
dc.subject.keyword | tumor necrosis factor-α | - |
dc.contributor.alternativeName | Kim, Jong Seok | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seok | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 221 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 440 | - |
dc.citation.endPage | 453 | - |
dc.identifier.bibliographicCitation | IMMUNOBIOLOGY, Vol.221(3) : 440-453, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45094 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.