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The role of cancer-associated fibroblasts in breast cancer pathobiology

Authors
 Yoon Yang Jung  ;  Hye Min Kim  ;  Ja Seung Koo 
Citation
 HISTOLOGY AND HISTOPATHOLOGY, Vol.31(4) : 371-378, 2016 
Journal Title
 HISTOLOGY AND HISTOPATHOLOGY 
ISSN
 0213-3911 
Issue Date
2016
MeSH
Breast Neoplasms/metabolism ; Breast Neoplasms/pathology* ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology* ; Humans ; Tumor Microenvironment*
Keywords
Breast cancer ; Cancer-associated fibroblast ; Tumor microenvironment
Abstract
The role of the tumor microenvironment (TME) is critical in cancer pathobiology. Of the components of the TME, cancer-associated fibroblasts (CAFs) play a major role. Breast cancer is a typical tumor type, forming abundant tumor stroma, and CAFs are involved in various aspects of breast cancer, including carcinogenesis, tumor progression, invasion, metastasis, inflammation, metabolism, therapy resistance, and prognosis. Various factors, such as growth factors, cytokines, hormones secreted from CAFs, paracrine effects promoted by the extracellular matrix (ECM), and mechanical pressure, are involved in cancer development, and there are various crosstalk and signaling pathways among CAFs, cancer cells, epithelial cells, and the ECM. Recent studies have evaluated the potential of CAFs as therapeutic targets in breast cancer. In this review, we discuss the role of CAFs and their clinical implications.
Full Text
http://www.hh.um.es/Abstracts/Vol_31/31_4/31_4_371.htm
DOI
10.14670/HH-11-700
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146449
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