Cited 16 times in
The role of cancer-associated fibroblasts in breast cancer pathobiology
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.date.accessioned | 2017-02-24T07:32:27Z | - |
dc.date.available | 2017-02-24T07:32:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146449 | - |
dc.description.abstract | The role of the tumor microenvironment (TME) is critical in cancer pathobiology. Of the components of the TME, cancer-associated fibroblasts (CAFs) play a major role. Breast cancer is a typical tumor type, forming abundant tumor stroma, and CAFs are involved in various aspects of breast cancer, including carcinogenesis, tumor progression, invasion, metastasis, inflammation, metabolism, therapy resistance, and prognosis. Various factors, such as growth factors, cytokines, hormones secreted from CAFs, paracrine effects promoted by the extracellular matrix (ECM), and mechanical pressure, are involved in cancer development, and there are various crosstalk and signaling pathways among CAFs, cancer cells, epithelial cells, and the ECM. Recent studies have evaluated the potential of CAFs as therapeutic targets in breast cancer. In this review, we discuss the role of CAFs and their clinical implications. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 371~378 | - |
dc.language | English | - |
dc.publisher | Histology and Histopathology | - |
dc.relation.isPartOf | HISTOLOGY AND HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Breast Neoplasms/metabolism | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts/metabolism | - |
dc.subject.MESH | Fibroblasts/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Tumor Microenvironment* | - |
dc.title | The role of cancer-associated fibroblasts in breast cancer pathobiology | - |
dc.type | Article | - |
dc.publisher.location | Spain | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Yang Jung | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.14670/HH-11-700 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04553 | - |
dc.relation.journalcode | J00993 | - |
dc.identifier.eissn | 1699-5848 | - |
dc.identifier.pmid | 26627101 | - |
dc.identifier.url | http://www.hh.um.es/Abstracts/Vol_31/31_4/31_4_371.htm | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Cancer-associated fibroblast | - |
dc.subject.keyword | Tumor microenvironment | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 371 | - |
dc.citation.endPage | 378 | - |
dc.identifier.bibliographicCitation | HISTOLOGY AND HISTOPATHOLOGY, Vol.31(4) : 371-378, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 45093 | - |
dc.type.rims | ART | - |
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