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Effects of preventive surgery for unruptured intracranial aneurysms on attention, executive function, learning and memory: a prospective cohort study

 Joonho Chung  ;  Jeong-Ho Seok  ;  Min A. Kwon  ;  Yong Bae Kim  ;  Jin-Yang Joo  ;  Chang-Ki Hong 
 ACTA NEUROCHIRURGICA, Vol.158(1) : 197-205, 2016 
Journal Title
Issue Date
Adult ; Attention/physiology* ; Executive Function/physiology* ; Female ; Humans ; Intracranial Aneurysm/surgery* ; Learning/physiology* ; Male ; Memory/physiology ; Middle Aged ; Outcome Assessment (Health Care)* ; Prophylactic Surgical Procedures/adverse effects* ; Prospective Studies
Brain dysfunction ; Endovascular coiling ; Intracranial aneurysms ; Microsurgical clipping ; Unruptured aneurysms
BACKGROUND: We prospectively evaluated the effects of preventive surgery for unruptured intracranial aneurysms on attention, executive function, learning and memory. METHODS: Between March 2012 and June 2013, 56 patients were recruited for this study. Fifty-one patients met the inclusion criteria and were enrolled. Inclusion criteria were as follows: (1) age ≤65 years and (2) planned microsurgery or endovascular surgery for unruptured intracranial aneurysm. Exclusion criteria were as follows: (1) preoperative intelligence quotient <80 (n = 3); (2) initial modified Rankin scale ≥1 (n = 1); (3) loss to follow-up (n = 1). An auditory controlled continuous performance test (ACCPT), word-color test (WCT) and verbal learning test (VLT) were performed before and after (6 months) preventive surgery. RESULTS: ACCPT (attention), WCT (executive function) and VLT (learning and memory) scores did not change significantly between the pre- and postoperative evaluations. The ACCPT, WCT, total VLT scores (verbal learning) and delayed VLT scores (memory) did not differ significantly between patients undergoing microsurgery and those undergoing endovascular surgery. However, ACCPT, WCT and delayed VLT scores decreased postoperatively in patients with leukoaraiosis on preoperative FLAIR images (OR 9.899, p = 0.041; OR 11.421, p = 0.006; OR 2.952, p = 0.024, respectively). CONCLUSIONS: Preventive surgery for unruptured intracranial aneurysms did not affect attention, executive function, learning or memory. However, patients with leukoaraiosis on FLAIR images might be prone to deficits in attention, executive function and memory postoperatively, whereas learning might not be affected.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Bae(김용배) ORCID logo https://orcid.org/0000-0003-2262-7157
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Chung, Joon Ho(정준호)
Joo, Jin Yang(주진양)
Hong, Chang Ki(홍창기) ORCID logo https://orcid.org/0000-0002-2761-0373
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