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Does education modify motor compensation in Parkinson's disease?

Authors
 Mun K. Sunwoo  ;  Jin Yong Hong  ;  Jae J. Lee  ;  Phil H. Lee  ;  Young H. Sohn 
Citation
 JOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.362 : 118-120, 2016 
Journal Title
 JOURNAL OF THE NEUROLOGICAL SCIENCES 
ISSN
 0022-510X 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Educational Status* ; Female ; Humans ; Male ; Mental Status Schedule ; Middle Aged ; Motor Activity/physiology* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/physiopathology* ; Parkinson Disease/psychology* ; Positron-Emission Tomography ; Retrospective Studies ; Tropanes/metabolism
Keywords
Dopamine transporter ; Education ; Motor deficits ; PET ; Parkinson's disease
Abstract
BACKGROUND: In Alzheimer's disease, higher educational attainment is associated with fewer cognitive deficits despite similar pathological lesions. In animal models of Parkinson's disease (PD), enhanced levels of cognitive and physical stimulation can reduce motor deficits due to dopaminergic neuronal loss. Therefore, in this study, we tested whether higher educational attainment has a beneficial influence on PD motor symptoms. METHODS: We included data from 182 patients with de novo PD without dementia, who underwent dopamine transporter (DAT) scans for an initial diagnostic work-up. Patients were divided into 2 groups according to their educational attainment; high education (HE-PD; ≥12years of education) and low education (LE-PD; <12years of education). RESULTS: The HE-PD group exhibited significantly higher mini-mental state exam scores, fewer motor deficits, and lower DAT binding to the posterior putamen than the LE-PD group, despite a similar duration of PD symptoms. A general linear model revealed that this difference in motor deficits remained statistically significant after controlling for potential confounding factors (p=0.032). CONCLUSION: These results suggest that higher educational attainment can lead to reduced motor deficits in PD despite greater reductions in dopamine levels.
Full Text
http://www.sciencedirect.com/science/article/pii/S0022510X16300326
DOI
10.1016/j.jns.2016.01.030
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sunwoo, Mun Kyung(선우문경)
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146435
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