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Cited 4 times in

Does education modify motor compensation in Parkinson's disease?

DC FieldValueLanguage
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.date.accessioned2017-02-24T03:46:05Z-
dc.date.available2017-02-24T03:46:05Z-
dc.date.issued2016-
dc.identifier.issn0022-510X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146435-
dc.description.abstractBACKGROUND: In Alzheimer's disease, higher educational attainment is associated with fewer cognitive deficits despite similar pathological lesions. In animal models of Parkinson's disease (PD), enhanced levels of cognitive and physical stimulation can reduce motor deficits due to dopaminergic neuronal loss. Therefore, in this study, we tested whether higher educational attainment has a beneficial influence on PD motor symptoms. METHODS: We included data from 182 patients with de novo PD without dementia, who underwent dopamine transporter (DAT) scans for an initial diagnostic work-up. Patients were divided into 2 groups according to their educational attainment; high education (HE-PD; ≥12years of education) and low education (LE-PD; <12years of education). RESULTS: The HE-PD group exhibited significantly higher mini-mental state exam scores, fewer motor deficits, and lower DAT binding to the posterior putamen than the LE-PD group, despite a similar duration of PD symptoms. A general linear model revealed that this difference in motor deficits remained statistically significant after controlling for potential confounding factors (p=0.032). CONCLUSION: These results suggest that higher educational attainment can lead to reduced motor deficits in PD despite greater reductions in dopamine levels.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent118~120-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF THE NEUROLOGICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins/metabolism-
dc.subject.MESHEducational Status*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMental Status Schedule-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMotor Activity/physiology*-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/physiopathology*-
dc.subject.MESHParkinson Disease/psychology*-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTropanes/metabolism-
dc.titleDoes education modify motor compensation in Parkinson's disease?-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorMun K. Sunwoo-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorJae J. Lee-
dc.contributor.googleauthorPhil H. Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1016/j.jns.2016.01.030-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.relation.journalcodeJ01897-
dc.identifier.eissn1878-5883-
dc.identifier.pmid26944130-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0022510X16300326-
dc.subject.keywordDopamine transporter-
dc.subject.keywordEducation-
dc.subject.keywordMotor deficits-
dc.subject.keywordPET-
dc.subject.keywordParkinson's disease-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.citation.volume362-
dc.citation.startPage118-
dc.citation.endPage120-
dc.identifier.bibliographicCitationJOURNAL OF THE NEUROLOGICAL SCIENCES, Vol.362 : 118-120, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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