Cited 17 times in
Human papillomavirus and epidermal growth factor receptor in oral cavity and oropharyngeal squamous cell carcinoma: Correlation with dynamic contrast-enhanced MRI parameters
DC Field | Value | Language |
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dc.contributor.author | 고윤우 | - |
dc.contributor.author | 김진아 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 최윤성 | - |
dc.contributor.author | 박미나 | - |
dc.date.accessioned | 2017-02-24T03:38:22Z | - |
dc.date.available | 2017-02-24T03:38:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0361-803X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146400 | - |
dc.description.abstract | OBJECTIVE: The objective of this study was to investigate differences in dynamic contrast-enhanced MRI (DCE-MRI) parameters on the basis of the status of human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) biomarkers in patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by use of histogram analysis. MATERIALS AND METHODS: A total of 22 consecutive patients with oral cavity and oropharyngeal SCC underwent DCE-MRI before receiving treatment. DCE parameter maps of the volume transfer constant (K(trans)), the flux rate constant (kep), and the extravascular extracellular volume fraction (ve) were obtained. The histogram parameters were calculated using the entire enhancing tumor volume and were compared between the patient subgroups on the basis of HPV and EGFR biomarker statuses. RESULTS: The cumulative histogram parameters of K(trans) and kep showed lower values in the HPV-negative and EFGR-overexpression group than in the HPV-positive EGFR-negative group. These differences were statistically significant for the mean (p = 0.009), 25th, 50th, and 75th percentile values of K(trans) and for the 25th percentile value of kep when correlated with HPV status in addition to the mean K(trans) value (p = 0.047) and kep value (p = 0.004) when correlated with EGFR status. No statistically significant difference in ve was found on the basis of HPV and EGFR status. CONCLUSION: DCE-MRI is useful for the assessment of the tumor microenvironment associated with HPV and EGFR biomarkers before treatment of patients with oral cavity and oropharyngeal SCC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Springfield, Ill., Thomas | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF ROENTGENOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers, Tumor/analysis | - |
dc.subject.MESH | Biomarkers, Tumor/isolation & purification | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell*/chemistry | - |
dc.subject.MESH | Carcinoma, Squamous Cell*/metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell*/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell*/virology | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mouth/chemistry | - |
dc.subject.MESH | Mouth/pathology | - |
dc.subject.MESH | Mouth/virology | - |
dc.subject.MESH | Mouth Neoplasms*/chemistry | - |
dc.subject.MESH | Mouth Neoplasms*/metabolism | - |
dc.subject.MESH | Mouth Neoplasms*/pathology | - |
dc.subject.MESH | Mouth Neoplasms*/virology | - |
dc.subject.MESH | Oropharyngeal Neoplasms*/chemistry | - |
dc.subject.MESH | Oropharyngeal Neoplasms*/metabolism | - |
dc.subject.MESH | Oropharyngeal Neoplasms*/pathology | - |
dc.subject.MESH | Oropharyngeal Neoplasms*/virology | - |
dc.subject.MESH | Papillomaviridae/isolation & purification* | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/metabolism* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Human papillomavirus and epidermal growth factor receptor in oral cavity and oropharyngeal squamous cell carcinoma: Correlation with dynamic contrast-enhanced MRI parameters | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | Yoon Seong Choi | - |
dc.contributor.googleauthor | Mina Park | - |
dc.contributor.googleauthor | Hyeong Ju Kwon | - |
dc.contributor.googleauthor | Yoon Woo Koh | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Jinna Kim | - |
dc.identifier.doi | 10.2214/AJR.15.14713 | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A01022 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A04137 | - |
dc.relation.journalcode | J00116 | - |
dc.identifier.eissn | 1546-3141 | - |
dc.identifier.pmid | 26797372 | - |
dc.identifier.url | http://www.ajronline.org/doi/abs/10.2214/AJR.15.14713 | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | epidermal growth factor receptor | - |
dc.subject.keyword | head and neck neoplasms | - |
dc.subject.keyword | human papillomavirus | - |
dc.subject.keyword | squamous cell carcinoma | - |
dc.contributor.alternativeName | Kho, Yoon Woo | - |
dc.contributor.alternativeName | Kim, Jinna | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Choi, Yoon Seong | - |
dc.contributor.affiliatedAuthor | Kho, Yoon Woo | - |
dc.contributor.affiliatedAuthor | Kim, Jinna | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Seong | - |
dc.citation.volume | 206 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 408 | - |
dc.citation.endPage | 413 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.206(2) : 408-413, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 47908 | - |
dc.type.rims | ART | - |
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