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Apathy and striatal dopamine defects in non-demented patients with Parkinson's disease

Authors
 Su Jin Chung  ;  Jae Jung Lee  ;  Jee Hyun Ham  ;  Phil Hyu Lee  ;  Young H. Sohn 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.23 : 62-65, 2016 
Journal Title
 PARKINSONISM & RELATED DISORDERS 
ISSN
 1353-8020 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Apathy/physiology* ; Corpus Striatum/diagnostic imaging ; Corpus Striatum/metabolism* ; Dopamine/metabolism* ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism* ; Parkinson Disease/psychology* ; Positron-Emission Tomography
Keywords
Apathy ; Dopamine ; PET ; Parkinson's disease ; Striatum
Abstract
INTRODUCTION: Apathy is a common, disabling symptom in Parkinson's disease (PD). The mechanisms underlying apathy in PD are still unclear, although they may be related to dysfunction in the meso-cortico-limbic circuit, including the ventral striatum. Thus, we performed this study to investigate whether dopamine depletion in the ventral striatum contributes to apathy in PD. METHODS: We conducted a survey of the degree of apathy (using the Korean version of the Apathy Evaluation Scale, AES-S) in 108 non-demented patients with PD who underwent dopamine transporter (DAT) positron emission tomography scans as an initial diagnostic work-up. Patients with AES-S scores of 37 or higher were defined as having apathetic PD. The Beck Depression Inventory (BDI) was administered to assess the severity of depression. Patients with BDI scores of 15 or higher were regarded as having depression. RESULTS: Apathetic patients (n = 34) tended to exhibit higher BDI scores than non-apathetic patients (n = 74); however, other clinical variables were comparable between the two groups. DAT activity in the striatal sub-regions was also similar between the two groups. Selecting only non-depressed patients, including 20 apathetic and 47 non-apathetic patients, did not alter the results. CONCLUSIONS: This study demonstrated that the pattern of striatal dopamine depletion does not contribute to the degree of apathy in early PD. Apathy in PD may be associated with extra-striatal lesions that accompany PD rather than striatal dopaminergic deficits.
Full Text
http://www.sciencedirect.com/science/article/pii/S1353802015300584
DOI
10.1016/j.parkreldis.2015.12.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Su Jin(정수진)
Ham, Jee Hyun(함지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146382
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