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Apathy and striatal dopamine defects in non-demented patients with Parkinson's disease

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author이재정-
dc.contributor.author이필휴-
dc.contributor.author정수진-
dc.contributor.author함지현-
dc.date.accessioned2017-02-24T03:35:01Z-
dc.date.available2017-02-24T03:35:01Z-
dc.date.issued2016-
dc.identifier.issn1353-8020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146382-
dc.description.abstractINTRODUCTION: Apathy is a common, disabling symptom in Parkinson's disease (PD). The mechanisms underlying apathy in PD are still unclear, although they may be related to dysfunction in the meso-cortico-limbic circuit, including the ventral striatum. Thus, we performed this study to investigate whether dopamine depletion in the ventral striatum contributes to apathy in PD. METHODS: We conducted a survey of the degree of apathy (using the Korean version of the Apathy Evaluation Scale, AES-S) in 108 non-demented patients with PD who underwent dopamine transporter (DAT) positron emission tomography scans as an initial diagnostic work-up. Patients with AES-S scores of 37 or higher were defined as having apathetic PD. The Beck Depression Inventory (BDI) was administered to assess the severity of depression. Patients with BDI scores of 15 or higher were regarded as having depression. RESULTS: Apathetic patients (n = 34) tended to exhibit higher BDI scores than non-apathetic patients (n = 74); however, other clinical variables were comparable between the two groups. DAT activity in the striatal sub-regions was also similar between the two groups. Selecting only non-depressed patients, including 20 apathetic and 47 non-apathetic patients, did not alter the results. CONCLUSIONS: This study demonstrated that the pattern of striatal dopamine depletion does not contribute to the degree of apathy in early PD. Apathy in PD may be associated with extra-striatal lesions that accompany PD rather than striatal dopaminergic deficits.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent62~65-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfPARKINSONISM & RELATED DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHApathy/physiology*-
dc.subject.MESHCorpus Striatum/diagnostic imaging-
dc.subject.MESHCorpus Striatum/metabolism*-
dc.subject.MESHDopamine/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/metabolism*-
dc.subject.MESHParkinson Disease/psychology*-
dc.subject.MESHPositron-Emission Tomography-
dc.titleApathy and striatal dopamine defects in non-demented patients with Parkinson's disease-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorSu Jin Chung-
dc.contributor.googleauthorJae Jung Lee-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.identifier.doi10.1016/j.parkreldis.2015.12.003-
dc.contributor.localIdA01982-
dc.contributor.localIdA03082-
dc.contributor.localIdA03270-
dc.contributor.localIdA04668-
dc.contributor.localIdA04338-
dc.relation.journalcodeJ02468-
dc.identifier.eissn1873-5126-
dc.identifier.pmid26717857-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1353802015300584-
dc.subject.keywordApathy-
dc.subject.keywordDopamine-
dc.subject.keywordPET-
dc.subject.keywordParkinson's disease-
dc.subject.keywordStriatum-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Jae Jung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameChung, Su Jin-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Jae Jung-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorChung, Su Jin-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.citation.volume23-
dc.citation.startPage62-
dc.citation.endPage65-
dc.identifier.bibliographicCitationPARKINSONISM & RELATED DISORDERS, Vol.23 : 62-65, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47890-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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