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Cancer theranosis using mono-disperse, mesoporous gold nanoparticles obtained via a robust, high-yield synthetic methodology

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dc.contributor.author서진석-
dc.contributor.author허용민-
dc.date.accessioned2017-02-24T03:30:57Z-
dc.date.available2017-02-24T03:30:57Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146362-
dc.description.abstractPorous noble metal nanoparticles exhibit many attractive nanoplasmonic features, and these structures have potential applications in many fields. However, such applications have been hindered by a lack of synthetic methods with the ability to mass-produce mono-disperse nanoparticles. Current synthetic approaches to porous gold nanostructure fabrication involve galvanic replacement approaches or electrochemical deposition methods that are generally limited by stringent multi-step protocols and relatively low yields. Here, we introduce the facile synthesis of scalable, mono-disperse, mesoporous gold nanoparticles (MPGNs) using an acidic emulsification method. This method facilitates high synthetic yields (>93%) and tunable particle sizes (130–400 nm). MPGNs exhibit enhanced payloads of gadolinium (Gd), a contrast agent for magnetic resonance imaging. Additionally, they permit photo-thermal conversion under near-infrared light (NIR) irradiation due to the increased surface area to volume ratio and the unique, structure-mediated LSPR effect. Specifically, MPGNs fabricated using our method provided Gd payloads 2–4 orders of magnitude greater than previously reported theranostic nano-probes. We believe that our novel synthetic technique will not only contribute to large-scale production of homogeneous porous gold nanoparticles, but will also promote further research in porous noble metal nanostructures.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent13554~13561-
dc.languageEnglish-
dc.publisherRoyal Society of Chemistry-
dc.relation.isPartOfRSC ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCancer theranosis using mono-disperse, mesoporous gold nanoparticles obtained via a robust, high-yield synthetic methodology-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorTaeksu Lee-
dc.contributor.googleauthorDoyeon Bang-
dc.contributor.googleauthorYong Wook Chang-
dc.contributor.googleauthorYuna Choi-
dc.contributor.googleauthorKwang Yeol Park-
dc.contributor.googleauthorAram Oh-
dc.contributor.googleauthorSeungmin Han-
dc.contributor.googleauthorSun Hee Kim-
dc.contributor.googleauthorKwangyeol Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1039/C5RA24772A-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ02626-
dc.identifier.eissn2046-2069-
dc.identifier.urlhttp://pubs.rsc.org/en/content/articlelanding/2016/ra/c5ra24772a#-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.citation.volume2016-
dc.citation.number6-
dc.citation.startPage13554-
dc.citation.endPage13561-
dc.identifier.bibliographicCitationRSC ADVANCES, Vol.2016(6) : 13554-13561, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47871-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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