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Magnetic Resonance Imaging after Completion of Neoadjuvant Chemotherapy Can Accurately Discriminate between No Residual Carcinoma and Residual Ductal Carcinoma In Situ in Patients with Triple-Negative Breast Cancer

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dc.contributor.author김민정-
dc.contributor.author김승일-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박형석-
dc.contributor.author손주혁-
dc.contributor.author윤정현-
dc.date.accessioned2017-02-24T03:29:00Z-
dc.date.available2017-02-24T03:29:00Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146355-
dc.description.abstractBACKGROUND: The accurate evaluation of favorable response to neoadjuvant chemotherapy (NCT) is critical to determine the extent of surgery. We investigated independent clinicopathological and radiological predictors to discriminate no residual carcinoma (ypT0) from residual ductal carcinoma in situ (ypTis) in breast cancer patients who received NCT. PATIENTS AND METHODS: Parameters of 117 patients attaining pathological complete response (CR) in the breast after NCT between January 2010 and December 2013 were retrospectively evaluated by univariate and multivariate analyses. All patients underwent mammography, ultrasound, and magnetic resonance imaging (MRI) before and after NCT. RESULTS: There were 67 (57.3%) patients with ypT0. These patients were associated with hormone receptor-negative status, human epidermal growth factor receptor-2 (HER2)-negative tumors, and a higher likelihood of breast-conservation surgery. Baseline mammographic and MRI presentation of the main lesion, absence of associated microcalcifications, shape, posterior features, and absence of calcifications on ultrasound were significantly associated with ypT0. CR in mammography, ultrasound, or MRI after NCT was also related to ypT0. By multivariate analysis, independent predictors of ypT0 were the triple-negative subtype [Odds ratio (OR), 4.23; 95% confidence interval (CI), 1.11-16.09] and CR in MRI after NCT (OR, 5.23; 95% CI, 1.53-17.85). Stratified analysis by breast cancer subtype demonstrated that MRI well predicted ypT0 in all subtypes except the HER2-positive subtype. In particular, of 40 triple-negative subtypes, 22 showed CR in MRI and 21 (95.5%) were ypT0 after NCT. CONCLUSION: Among imaging modalities, breast MRI can potentially distinguish between ypT0 and ypTis after NCT, especially in patients with triple-negative breast cancer. This information can help clinicians evaluate tumor response to NCT and plan surgery for breast cancer patients of all subtypes except for those with HER2-enriched tumors after NCT.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0149347-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHBreast/pathology-
dc.subject.MESHCarcinoma/diagnosis*-
dc.subject.MESHCarcinoma/drug therapy-
dc.subject.MESHCarcinoma/pathology-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/diagnosis*-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/drug therapy-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/pathology-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHDiagnosis, Computer-Assisted-
dc.subject.MESHFalse Positive Reactions-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMagnetic Resonance Imaging*-
dc.subject.MESHMammography-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHROC Curve-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTriple Negative Breast Neoplasms/diagnosis*-
dc.subject.MESHTriple Negative Breast Neoplasms/drug therapy-
dc.subject.MESHTriple Negative Breast Neoplasms/pathology-
dc.subject.MESHUltrasonography, Mammary-
dc.titleMagnetic Resonance Imaging after Completion of Neoadjuvant Chemotherapy Can Accurately Discriminate between No Residual Carcinoma and Residual Ductal Carcinoma In Situ in Patients with Triple-Negative Breast Cancer-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJoohyuk Sohn-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorMin Jung Kim-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorByeong-Woo Park-
dc.identifier.doi10.1371/journal.pone.0149347-
dc.contributor.localIdA00473-
dc.contributor.localIdA00658-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01753-
dc.contributor.localIdA01995-
dc.contributor.localIdA02595-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid26866475-
dc.contributor.alternativeNameKim, Min Jung-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameSohn, Joo Hyuk-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.affiliatedAuthorKim, Min Jung-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorSohn, Joo Hyuk-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.citation.volume11-
dc.citation.number2-
dc.citation.startPagee0149347-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(2) : e0149347, 2016-
dc.date.modified2017-02-24-
dc.identifier.rimsid47864-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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