0 230

Cited 12 times in

Hippocampus-Sparing Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Multiple Brain Metastases From Lung Adenocarcinoma: Early Response and Dosimetric Evaluation.

Authors
 Kyung Hwan Kim  ;  Byoung Chul Cho  ;  Chang Geol Lee  ;  Hye Ryun Kim  ;  Yang Gun Suh  ;  Jun Won Kim  ;  Chihwan Choi  ;  Jong Geal Baek  ;  Jaeho Cho 
Citation
 TECHNOLOGY IN CANCER RESEARCH & TREATMENT, Vol.15(1) : 122-129, 2016 
Journal Title
 TECHNOLOGY IN CANCER RESEARCH & TREATMENT 
ISSN
 1533-0346 
Issue Date
2016
MeSH
Adenocarcinoma/mortality ; Adenocarcinoma/radiotherapy* ; Adenocarcinoma/secondary ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/mortality ; Brain Neoplasms/radiotherapy* ; Brain Neoplasms/secondary ; Dose Fractionation ; Dose-Response Relationship, Radiation ; Female ; Hippocampus/pathology ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/radiotherapy* ; Male ; Middle Aged ; Organ Sparing Treatments ; Radiotherapy Planning, Computer-Assisted ; Retrospective Studies ; Treatment Outcome ; Tumor Burden/radiation effects
Keywords
brain metastasis ; hippocampus ; lung adenocarcinoma ; radiotherapy ; tumor volume
Abstract
In this study, the volume response and treatment outcome after hippocampus-sparing whole-brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB) using tomotherapy were evaluated. Patients with primary lung adenocarcinoma and multiple brain metastases who had a Karnofsky performance status ≥ 70 and exhibited well-controlled extracranial disease were treated. The prescribed dose was administered in 10 to 14 fractions as 25 to 28 Gy to whole-brain parenchyma, as 40 to 48 Gy to the gross metastatic lesion, and as 30 to 42 Gy to a 5-mm margin to the metastatic lesion. Double-dose gadolinium contrast-enhanced magnetic resonance imaging at 1-mm slice thickness was performed before treatment and at 1, 4, and 7 months post-treatment. The tumor volume reduction ratio was calculated for each follow-up. Between July 2011 and September 2012, 11 patients with 70 lesions were included in this analysis. The median number of lesions per patient was 4 (range, 2-15). The median initial tumor volume was 0.235 cm(3) (range, 0.020-10.140 cm(3)). The treatment plans were evaluated regarding conformation number (CN), target coverage (TC), and homogeneity index (HI). The median follow-up duration was 14 months (range, 3-25 months) and the 1-year intracranial control rate was 67%. The tumor volume reduction was most prominent during the first month with a median reduction rate of 0.717 (range, -0.190 to 1.000). Complete remission was seen in 22 (33%) lesions, and 45 (64%) lesions showed more than 65% reduction in tumor volume. The CN, TC, and HI values were comparable to that of previous studies, and the mean hippocampal dose was 13.65 Gy. No treatment breaks or ≥ G3 acute toxicities were observed during or after treatment. The HS-WBRT with SIB in patients with multiple brain metastases was effective and feasible for volume reduction and showed excellent intracranial control.
Full Text
http://tct.sagepub.com/content/15/1/122.long
DOI
10.1177/1533034614566993
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jun Won(김준원) ORCID logo https://orcid.org/0000-0003-1358-364X
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Suh, Yang Gun(서양권)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Choi, Chi Hwan(최치환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146333
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse