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Pseudoprogression in glioblastoma patients: the impact of extent of resection

DC FieldValueLanguage
dc.contributor.author강석구-
dc.contributor.author이규성-
dc.contributor.author이승구-
dc.contributor.author장종희-
dc.contributor.author조재호-
dc.contributor.author최혜진-
dc.contributor.author홍창기-
dc.contributor.author김선호-
dc.contributor.author김세훈-
dc.contributor.author김의현-
dc.contributor.author노태훈-
dc.contributor.author박현호-
dc.contributor.author서창옥-
dc.contributor.author안성수-
dc.date.accessioned2017-02-24T03:20:33Z-
dc.date.available2017-02-24T03:20:33Z-
dc.date.issued2016-
dc.identifier.issn0167-594X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/146319-
dc.description.abstractPseudoprogression (psPD) is a radiation-induced toxicity that has substantial neurological consequence in glioblastoma (GBM) patients. MGMT promoter methylation has been shown to be an important prognostic factor of psPD, but the significance of extent of resection (EOR) remains unclear. We performed a retrospective analysis on newly diagnosed GBM patients with assessable MGMT promoter status who underwent the Stupp protocol. EOR was grouped into gross total resection (GTR), subtotal resection (STR), partial resection (PR) and stereotactic biopsy. Contrast enhancing lesion enlargement was classified as psPD or non-psPD. Among a total of 101 patients, GTR, STR, PR and stereotactic biopsy was performed in 57 (56.4%), 34 (33.7%), 9 (8.9%) and 1 patient (1%), respectively. Follow-up imaging at the end of Stupp protocol classified 45 patients (44.6%) as psPD and 56 (55.4%) as non-psPD. psPD was observed in 24 (61.5%) of 39 patients with methylated MGMT promoter and 21 (33.9%) of 62 patients with unmethylated MGMT promoter (p < 0.01). psPD was documented in 17 (29.8%), 19 (55.9%), 8 (88.9%) and 1 (100%) patient with GTR, STR, PR and stereotactic biopsy (p < 0.01), respectively. On multivariate analysis MGMT promoter status (OR 3.36, 95% CI 1.36-8.34) and EOR (OR 4.12, 95% CI 1.71-9.91) were independent predictors of psPD. A Cox proportional hazards model showed that MGMT status (HR 2.51, p < 0.01) and EOR (HR 2.99, p < 0.01) significantly influenced survival. MGMT status and EOR have a significant impact on psPD. GTR can reduce the side effects of psPD and prolong survival.-
dc.description.statementOfResponsibilityrestriction-
dc.format.extent559~566-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfJournal of Neuro-Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBrain Neoplasms/pathology*-
dc.subject.MESHBrain Neoplasms/surgery*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlioblastoma/pathology*-
dc.subject.MESHGlioblastoma/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeurosurgical Procedures/adverse effects*-
dc.subject.MESHPostoperative Complications*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.subject.MESHYoung Adult-
dc.titlePseudoprogression in glioblastoma patients: the impact of extent of resection-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorHun Ho Park-
dc.contributor.googleauthorTae Hoon Roh-
dc.contributor.googleauthorSeok Gu Kang-
dc.contributor.googleauthorEui Hyun Kim-
dc.contributor.googleauthorChang-Ki Hong-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorSeung Koo Lee-
dc.contributor.googleauthorHye Jin Choi-
dc.contributor.googleauthorJaeho Cho-
dc.contributor.googleauthorSun Ho Kim-
dc.contributor.googleauthorKyu-Sung Lee-
dc.contributor.googleauthorChang-Ok Suh-
dc.contributor.googleauthorJong Hee Chang-
dc.identifier.doi10.1007/s11060-015-2001-0-
dc.contributor.localIdA00036-
dc.contributor.localIdA02682-
dc.contributor.localIdA02912-
dc.contributor.localIdA03470-
dc.contributor.localIdA03901-
dc.contributor.localIdA04219-
dc.contributor.localIdA04445-
dc.contributor.localIdA00560-
dc.contributor.localIdA00610-
dc.contributor.localIdA00837-
dc.contributor.localIdA01300-
dc.contributor.localIdA01750-
dc.contributor.localIdA01919-
dc.contributor.localIdA02234-
dc.relation.journalcodeJ01629-
dc.identifier.pmid26608521-
dc.identifier.urlhttp://link.springer.com/article/10.1007/s11060-015-2001-0-
dc.subject.keywordExtent of resection-
dc.subject.keywordGlioblastoma-
dc.subject.keywordMGMT promoter status-
dc.subject.keywordPseudoprogression-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.alternativeNameLee, Kyu Sung-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.alternativeNameChoi, Hye Jin-
dc.contributor.alternativeNameHong, Chang Ki-
dc.contributor.alternativeNameKim, Sun Ho-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Eui Hyun-
dc.contributor.alternativeNameRoh, Tae Hoon-
dc.contributor.alternativeNamePark, Hun Ho-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.affiliatedAuthorKang, Seok Gu-
dc.contributor.affiliatedAuthorLee, Kyu Sung-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.contributor.affiliatedAuthorChoi, Hye Jin-
dc.contributor.affiliatedAuthorHong, Chang Ki-
dc.contributor.affiliatedAuthorKim, Sun Ho-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorKim, Eui Hyun-
dc.contributor.affiliatedAuthorRoh, Tae Hoon-
dc.contributor.affiliatedAuthorPark, Hun Ho-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.citation.volume126-
dc.citation.number3-
dc.citation.startPage559-
dc.citation.endPage566-
dc.identifier.bibliographicCitationJournal of Neuro-Oncology, Vol.126(3) : 559-566, 2016-
dc.date.modified2017-02-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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