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Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson’s disease

Authors
 Jae Jung Lee  ;  Jungsu S. Oh  ;  Jee H. Ham  ;  Dong H. Lee  ;  Injoo Lee  ;  Young H. Sohn  ;  Jae S. Kim  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.38 : 197-204, 2016 
Journal Title
 NEUROBIOLOGY OF AGING 
ISSN
 0197-4580 
Issue Date
2016
MeSH
Aged ; Body Mass Index* ; Corpus Striatum/metabolism* ; Dopamine/deficiency* ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Parkinson Disease/etiology* ; Parkinson Disease/metabolism* ; Substantia Nigra/metabolism*
Keywords
Body mass index ; Dopamine transporter activity ; Parkinson's disease
Abstract
Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
Full Text
http://www.sciencedirect.com/science/article/pii/S019745801500576X
DOI
10.1016/j.neurobiolaging.2015.11.009
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/146290
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