Cited 37 times in
Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson’s disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이재정 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 함지현 | - |
dc.date.accessioned | 2017-02-24T03:15:19Z | - |
dc.date.available | 2017-02-24T03:15:19Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/146290 | - |
dc.description.abstract | Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 197~204 | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Body Mass Index* | - |
dc.subject.MESH | Corpus Striatum/metabolism* | - |
dc.subject.MESH | Dopamine/deficiency* | - |
dc.subject.MESH | Dopamine/metabolism | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Parkinson Disease/etiology* | - |
dc.subject.MESH | Parkinson Disease/metabolism* | - |
dc.subject.MESH | Substantia Nigra/metabolism* | - |
dc.title | Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson’s disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Jae Jung Lee | - |
dc.contributor.googleauthor | Jungsu S. Oh | - |
dc.contributor.googleauthor | Jee H. Ham | - |
dc.contributor.googleauthor | Dong H. Lee | - |
dc.contributor.googleauthor | Injoo Lee | - |
dc.contributor.googleauthor | Young H. Sohn | - |
dc.contributor.googleauthor | Jae S. Kim | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2015.11.009 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A03082 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04338 | - |
dc.relation.journalcode | J02322 | - |
dc.identifier.eissn | 1558-1497 | - |
dc.identifier.pmid | 26827658 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S019745801500576X | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Dopamine transporter activity | - |
dc.subject.keyword | Parkinson's disease | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Lee, Jae Jung | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.alternativeName | Ham, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | Lee, Jae Jung | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Ham, Jee Hyun | - |
dc.citation.volume | 38 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, Vol.38 : 197-204, 2016 | - |
dc.date.modified | 2017-02-24 | - |
dc.identifier.rimsid | 51378 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.