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Value of 18F-FDG PET/CT for Predicting the World Health Organization Malignant Grade of Thymic Epithelial Tumors: Focused in Volume-Dependent Parameters.

Authors
 Seong Yong Park  ;  Arthur Cho  ;  Mi Kyung Bae  ;  Chang Young Lee  ;  Dae Joon Kim  ;  Kyung Young Chung 
Citation
 CLINICAL NUCLEAR MEDICINE, Vol.41(1) : 15-20, 2016 
Journal Title
 CLINICAL NUCLEAR MEDICINE 
ISSN
 0363-9762 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Female ; Fluorodeoxyglucose F18* ; Glycolysis ; Humans ; Male ; Middle Aged ; Multimodal Imaging* ; Neoplasm Grading ; Neoplasms, Glandular and Epithelial/diagnosis* ; Neoplasms, Glandular and Epithelial/metabolism ; Neoplasms, Glandular and Epithelial/pathology* ; Positron-Emission Tomography* ; ROC Curve ; Retrospective Studies ; Thymoma/pathology ; Thymus Neoplasms/diagnosis* ; Thymus Neoplasms/metabolism ; Thymus Neoplasms/pathology* ; Tomography, X-Ray Computed* ; Tumor Burden*
Keywords
thymic epithelial tumors ; PET/CT ; WHO classification ; volume-dependent parameter
Abstract
PURPOSE: We investigated whether preoperative parameters of 18F-FDG PET/CT were correlated with the World Health Organization (WHO) classification and/or Masaoka staging of thymic epithelial tumors. PATIENTS AND METHODS: We reviewed 61 patients retrospectively who were diagnosed with thymic epithelial tumors after surgical resection and PET/CT. A volume of interest was drawn on the primary lesion, using an SUV cutoff of 2.5, and metabolic indices such as SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. RESULTS: There were 24 male patients (38.7%), and the mean (SD) age was 50.23 (12.54) years. The mean (SD) tumor size was 6.11 (3.41) cm. There were 22 low-risk thymomas (36.9%) (A, AB, B1), 32 high-risk thymomas (51.6%), and 7 thymic carcinomas (11.5%). The Masaoka stage was I in 15 (24.6%), II in 30 (49.2%), III in 11 (18.0%), and IV in 5 patients (8.2%). Mean (SD) SUVmax was 3.43 (1.01) in low-risk thymomas, 4.42 (1.70) in high-risk thymomas, and 8.23 (2.61) in thymic carcinoma; the differences were significant (P < 0.001). Mean (SD) MTV and TLG were 90.74 (114.56) and 229.36 (300.56) in low-risk thymomas, 80.82 (112.49) and 233.93 (340.91) in high-risk thymomas, and 90.63 (90.74) and 390.94 (437.62), respectively, in thymic carcinomas. MTV and TLG showed no correlation with the WHO classification. On receiver operating characteristic curve analysis, the cutoff value for discriminating thymomas and thymic carcinomas was 5.05. SUVmax and TLG were correlated with Masaoka stage. CONCLUSIONS: Although volume-dependent parameters were not correlated with the WHO classification, a significant relationship was observed between SUVmax and WHO classification and Masaoka stage.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003072-201601000-00003&LSLINK=80&D=ovft
DOI
10.1097/RLU.0000000000001032
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
Cho, Arthur Eung Hyuck(조응혁) ORCID logo https://orcid.org/0000-0001-8670-2473
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/145525
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