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Burkholderia Sepsis in Children as a Hospital-Acquired Infection

Authors
 Kyu Yeun Kim  ;  Dongeun Yong  ;  Kyungwon Lee  ;  Ho-Seong Kim  ;  Dong Soo Kim 
Citation
 Yonsei Medical Journal, Vol.57(1) : 97-102, 2016 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2016
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/epidemiology* ; Burkholderia Infections/blood ; Burkholderia Infections/drug therapy ; Burkholderia Infections/epidemiology* ; Burkholderia cepacia/drug effects ; Burkholderia cepacia/isolation & purification* ; Child ; Child, Preschool ; Cross Infection/blood ; Cross Infection/diagnosis* ; Cross Infection/drug therapy ; Cross Infection/mortality ; Disease Outbreaks ; Female ; Humans ; Incidence ; Infant ; Intensive Care Units* ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Treatment Outcome ; Young Adult
Keywords
Burkholderia cepacia ; child ; hospital infection ; sepsis
Abstract
PURPOSE: Hospital-acquired Burkholderia cepacia (B. cepacia) infection are not commonly recorded in patients without underlying lung disease, such as cystic fibrosis and chronic granulomatous disease. However, in 2014, B. cepacia appeared more frequently in pediatric blood samples than in any other year. In order to access this situation, we analyzed the clinical characteristics of B. cepacia infections in pediatric patients at our hospital. MATERIALS AND METHODS: We conducted a retrospective study of blood isolates of B. cepacia taken at our hospital between January 2004 and December 2014. Patient clinical data were obtained by retrospective review of electronic medical records. We constructed a dendrogram for B. cepacia isolates from two children and five adult patients. RESULTS: A total of 14 pediatric patients and 69 adult patients were identified as having B. cepacia bacteremia. In 2014, higher rates of B. cepacia bacteremia were observed in children. Most of them required Intensive Care Unit (ICU) care (12/14). In eleven children, sputum cultures were examined, and five of these children had the same strain of B. cepacia that grew out from their blood samples. Antibiotics were administered based on antibiotic sensitivity results. Four children expired despite treatment. Compared to children, there were no demonstrative differences in adults, except for history of ICU care. CONCLUSION: Although there were not many pediatric cases at our hospital, awareness of colonization through hospital-acquired infection and effective therapy for infection of B. cepacia is needed, as it can cause mortality and morbidity.
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DOI
10.3349/ymj.2016.57.1.97
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김규연(Kim, Kyu Yeun)
김동수(Kim, Dong Soo)
김호성(Kim, Ho Seong) ORCID logo https://orcid.org/0000-0003-1135-099X
용동은(Yong, Dong Eun) ORCID logo https://orcid.org/0000-0002-1225-8477
이경원(Lee, Kyungwon) ORCID logo https://orcid.org/0000-0003-3788-2134
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/145512
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