Cited 18 times in
In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor
DC Field | Value | Language |
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dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 구민희 | - |
dc.date.accessioned | 2017-01-19T12:57:10Z | - |
dc.date.available | 2017-01-19T12:57:10Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/145506 | - |
dc.description.abstract | Biomedical in vivo sensing methods in the near-infrared (NIR) range, which that provide relatively high photon transparency, separation from auto-fluorescence background, and extended sensitivity, are being used increasingly for non-invasive mapping and monitoring of molecular events in cancer cells. In this study, we fabricated an NIR fluorogenic nanosensor based on the nanoparticle surface energy transfer effect, by conjugation of fluorescent proteolytic enzyme-specific cleavable peptides with gold nanorods (GNRs). Membrane-anchored membrane type 1-matrix metalloproteinases (MT1-MMPs), a family of zinc-dependent proteolytic enzymes, can induce the metastatic potential of cancer cells by promoting degradation of the extracellular matrix. Therefore, sensitive detection of MT1-MMP activity can provide essential information in the clinical setting. We have applied in vivo NIR sensing to evaluate MT1-MMP activity, as an NIR imaging target, in an MT1-MMP-expressing metastatic tumor mouse model. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.format.extent | 471~477 | - |
dc.publisher | Elsevier Advanced Technology | - |
dc.relation.isPartOf | BIOSENSORS & BIOELECTRONICS | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Enzyme Activation | - |
dc.subject.MESH | Fluorescence Resonance Energy Transfer/instrumentation* | - |
dc.subject.MESH | Gold/chemistry | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 14/metabolism* | - |
dc.subject.MESH | Metal Nanoparticles/chemistry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nanotubes/chemistry | - |
dc.subject.MESH | Neoplasms, Experimental/enzymology* | - |
dc.subject.MESH | Neoplasms, Experimental/secondary* | - |
dc.subject.MESH | Spectroscopy, Near-Infrared/instrumentation* | - |
dc.title | In vivo sensing of proteolytic activity with an NSET-based NIR fluorogenic nanosensor | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Yoochan Hong | - |
dc.contributor.googleauthor | Dan Heo | - |
dc.contributor.googleauthor | Eugene Lee | - |
dc.contributor.googleauthor | Seungyeon Hwang | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.identifier.doi | 10.1016/j.bios.2015.09.067 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A00191 | - |
dc.relation.journalcode | J00330 | - |
dc.identifier.eissn | 1873-4235 | - |
dc.identifier.pmid | 26454829 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0956566315304632 | - |
dc.subject.keyword | Fluorogenic | - |
dc.subject.keyword | Gold nanorod | - |
dc.subject.keyword | Membrane type 1-matrix metalloproteinase | - |
dc.subject.keyword | Nanoparticle surface energy transfer | - |
dc.subject.keyword | Nanosensor | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.citation.volume | 77 | - |
dc.citation.startPage | 471 | - |
dc.citation.endPage | 477 | - |
dc.identifier.bibliographicCitation | BIOSENSORS & BIOELECTRONICS, Vol.77 : 471-477, 2016 | - |
dc.date.modified | 2017-01-16 | - |
dc.identifier.rimsid | 47362 | - |
dc.type.rims | ART | - |
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