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Significance of 99mTc-ECD SPECT in Acute and Subacute Ischemic Stroke: Comparison with MR Images Including Diffusion and Perfusion Weighted Images

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dc.contributor.author김동익-
dc.contributor.author김현숙-
dc.contributor.author서범천-
dc.contributor.author이병인-
dc.contributor.author이승구-
dc.contributor.author이종두-
dc.contributor.author정은기-
dc.contributor.author정태섭-
dc.date.accessioned2016-05-16T11:32:14Z-
dc.date.available2016-05-16T11:32:14Z-
dc.date.issued2002-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144771-
dc.description.abstract99mTc-ECD SPECT is valuable for the evaluation of cell viability and function. The purpose of the present study was to evaluate the significance of 99mTc-ECD brain SPECT in ischemic stroke. We compared 99mTc-ECD brain SPECT with perfusion and diffusion weighted images (PWI, DWI). Ten patients with acute and early subacute ischemic stroke were included in this prospective study. T2-weighted images (T2WI), DWI, PWI and 99mTc-ECD SPECT were obtained during both the acute/early subacute and late subacute stages. In the case of PWI, time to peak (TTP) and regional cerebral blood volume (rCBV) maps were obtained. The rCBV map and 99mTc-ECD SPECT images were compared in 8 lesions using Δ AI. The asymmetry index (AI) was calculated as (Ci - Cc) × 200 / (Ci + Cc); where Ci is the mean number of pixel counts of an ipsilateral lesion and Cc is the mean number of pixel counts of the normal contralateral hemisphere. Δ AI was defined as AIacute - AIsubacute in the ischemic core and periphery. PWI and 99mTc-ECD SPECT detected new lesions of the hyperacute stage or of evolving stroke more accurately than T2WI and DWI. 99mTc-ECD SPECT was able to localize the infarct core and peri-infarct ischemia in all lesions in both the acute and the subacute stages. Δ AI was higher in the rCBV map than in the 99mTc-ECD SPECT images in the ischemic core (p = 0.063) and in the periphery (p = 0.091). In the 99mTc-ECD SPECT images, Δ AI was higher in the ischemic core than in the periphery (p = 0.028). During the subacute stage, 99mTc-ECD SPECT detected all the lesions without the pseudonormalization seen in the MR images of 5/11 lesions. Based on this study, 99mTc-ECD SPECT is comparable to PWI in terms of its ability to detect acute stroke and is more useful than PWI in the case of subacute infarction.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBrain Ischemia/complications*-
dc.subject.MESHCysteine/analogs & derivatives*-
dc.subject.MESHDiffusion-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrganotechnetium Compounds*-
dc.subject.MESHPerfusion-
dc.subject.MESHRadiopharmaceuticals*-
dc.subject.MESHStroke/diagnosis*-
dc.subject.MESHStroke/etiology*-
dc.subject.MESHTomography, Emission-Computed, Single-Photon*-
dc.titleSignificance of 99mTc-ECD SPECT in Acute and Subacute Ischemic Stroke: Comparison with MR Images Including Diffusion and Perfusion Weighted Images-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorHyun Sook Kim-
dc.contributor.googleauthorDong Ik Kim-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorEun Kee Jeong-
dc.contributor.googleauthorTae Sub Chung-
dc.contributor.googleauthorPyeong Ho Yoon-
dc.contributor.googleauthorSeung Koo Lee-
dc.contributor.googleauthorEun Ju Kim-
dc.contributor.googleauthorYong Kyu Yoon-
dc.contributor.googleauthorBum Chun Suh-
dc.contributor.googleauthorByung In Lee-
dc.identifier.doi10.3349/ymj.2002.43.2.211-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00408-
dc.contributor.localIdA01883-
dc.contributor.localIdA02616-
dc.contributor.localIdA02797-
dc.contributor.localIdA02912-
dc.contributor.localIdA03138-
dc.contributor.localIdA03684-
dc.contributor.localIdA03751-
dc.contributor.localIdA01119-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid11971215-
dc.subject.keywordCerebral infarction-
dc.subject.keywordtechnetium-99m-ethyl cysteinate dimer-
dc.subject.keywordsingle photon emission computed tomography-
dc.subject.keywordmagnetic resonance imaging-
dc.subject.keyworddiffusion-
dc.subject.keywordperfusion-
dc.contributor.alternativeNameKim, Dong Ik-
dc.contributor.alternativeNameKim, Hyun Sook-
dc.contributor.alternativeNameSuh, Bum Chun-
dc.contributor.alternativeNameYoon, Pyeong Ho-
dc.contributor.alternativeNameLee, Byung In-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameLee, Jong Doo-
dc.contributor.alternativeNameJeong, Eun Kee-
dc.contributor.alternativeNameChung, Tae Sub-
dc.contributor.affiliatedAuthorKim, Dong Ik-
dc.contributor.affiliatedAuthorSuh, Bum Chun-
dc.contributor.affiliatedAuthorYoon, Pyeong Ho-
dc.contributor.affiliatedAuthorLee, Byung In-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorLee, Jong Doo-
dc.contributor.affiliatedAuthorJeong, Eun Kee-
dc.contributor.affiliatedAuthorChung, Tae Sub-
dc.contributor.affiliatedAuthorKim, Hyun Sook-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number2-
dc.citation.startPage211-
dc.citation.endPage222-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.43(2) : 211-222, 2002-
dc.identifier.rimsid53023-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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