Cited 11 times in
Significance of 99mTc-ECD SPECT in Acute and Subacute Ischemic Stroke: Comparison with MR Images Including Diffusion and Perfusion Weighted Images
DC Field | Value | Language |
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dc.contributor.author | 김동익 | - |
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 서범천 | - |
dc.contributor.author | 이병인 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 이종두 | - |
dc.contributor.author | 정은기 | - |
dc.contributor.author | 정태섭 | - |
dc.date.accessioned | 2016-05-16T11:32:14Z | - |
dc.date.available | 2016-05-16T11:32:14Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144771 | - |
dc.description.abstract | 99mTc-ECD SPECT is valuable for the evaluation of cell viability and function. The purpose of the present study was to evaluate the significance of 99mTc-ECD brain SPECT in ischemic stroke. We compared 99mTc-ECD brain SPECT with perfusion and diffusion weighted images (PWI, DWI). Ten patients with acute and early subacute ischemic stroke were included in this prospective study. T2-weighted images (T2WI), DWI, PWI and 99mTc-ECD SPECT were obtained during both the acute/early subacute and late subacute stages. In the case of PWI, time to peak (TTP) and regional cerebral blood volume (rCBV) maps were obtained. The rCBV map and 99mTc-ECD SPECT images were compared in 8 lesions using Δ AI. The asymmetry index (AI) was calculated as (Ci - Cc) × 200 / (Ci + Cc); where Ci is the mean number of pixel counts of an ipsilateral lesion and Cc is the mean number of pixel counts of the normal contralateral hemisphere. Δ AI was defined as AIacute - AIsubacute in the ischemic core and periphery. PWI and 99mTc-ECD SPECT detected new lesions of the hyperacute stage or of evolving stroke more accurately than T2WI and DWI. 99mTc-ECD SPECT was able to localize the infarct core and peri-infarct ischemia in all lesions in both the acute and the subacute stages. Δ AI was higher in the rCBV map than in the 99mTc-ECD SPECT images in the ischemic core (p = 0.063) and in the periphery (p = 0.091). In the 99mTc-ECD SPECT images, Δ AI was higher in the ischemic core than in the periphery (p = 0.028). During the subacute stage, 99mTc-ECD SPECT detected all the lesions without the pseudonormalization seen in the MR images of 5/11 lesions. Based on this study, 99mTc-ECD SPECT is comparable to PWI in terms of its ability to detect acute stroke and is more useful than PWI in the case of subacute infarction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brain Ischemia/complications* | - |
dc.subject.MESH | Cysteine/analogs & derivatives* | - |
dc.subject.MESH | Diffusion | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organotechnetium Compounds* | - |
dc.subject.MESH | Perfusion | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Stroke/diagnosis* | - |
dc.subject.MESH | Stroke/etiology* | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon* | - |
dc.title | Significance of 99mTc-ECD SPECT in Acute and Subacute Ischemic Stroke: Comparison with MR Images Including Diffusion and Perfusion Weighted Images | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Hyun Sook Kim | - |
dc.contributor.googleauthor | Dong Ik Kim | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Eun Kee Jeong | - |
dc.contributor.googleauthor | Tae Sub Chung | - |
dc.contributor.googleauthor | Pyeong Ho Yoon | - |
dc.contributor.googleauthor | Seung Koo Lee | - |
dc.contributor.googleauthor | Eun Ju Kim | - |
dc.contributor.googleauthor | Yong Kyu Yoon | - |
dc.contributor.googleauthor | Bum Chun Suh | - |
dc.contributor.googleauthor | Byung In Lee | - |
dc.identifier.doi | 10.3349/ymj.2002.43.2.211 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A01883 | - |
dc.contributor.localId | A02616 | - |
dc.contributor.localId | A02797 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A03684 | - |
dc.contributor.localId | A03751 | - |
dc.contributor.localId | A01119 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 11971215 | - |
dc.subject.keyword | Cerebral infarction | - |
dc.subject.keyword | technetium-99m-ethyl cysteinate dimer | - |
dc.subject.keyword | single photon emission computed tomography | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | diffusion | - |
dc.subject.keyword | perfusion | - |
dc.contributor.alternativeName | Kim, Dong Ik | - |
dc.contributor.alternativeName | Kim, Hyun Sook | - |
dc.contributor.alternativeName | Suh, Bum Chun | - |
dc.contributor.alternativeName | Yoon, Pyeong Ho | - |
dc.contributor.alternativeName | Lee, Byung In | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Lee, Jong Doo | - |
dc.contributor.alternativeName | Jeong, Eun Kee | - |
dc.contributor.alternativeName | Chung, Tae Sub | - |
dc.contributor.affiliatedAuthor | Kim, Dong Ik | - |
dc.contributor.affiliatedAuthor | Suh, Bum Chun | - |
dc.contributor.affiliatedAuthor | Yoon, Pyeong Ho | - |
dc.contributor.affiliatedAuthor | Lee, Byung In | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Lee, Jong Doo | - |
dc.contributor.affiliatedAuthor | Jeong, Eun Kee | - |
dc.contributor.affiliatedAuthor | Chung, Tae Sub | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Sook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 43 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 222 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.43(2) : 211-222, 2002 | - |
dc.identifier.rimsid | 53023 | - |
dc.type.rims | ART | - |
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