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Aortic Valve Involvement in Behcet`s Disease. A Clinical Study of 9 Patients

Authors
 Choong Won Lee  ;  Jisoo Lee  ;  Won Ki Lee  ;  Chan Hee Lee  ;  Chang Hee Suh  ;  Chang Ho Song  ;  Yong Beom Park  ;  Soo Kon Lee  ;  Yong Soon Won 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.17(1) : 51-56, 2002 
Journal Title
 KOREAN JOURNAL OF INTERNAL MEDICINE 
ISSN
 1226-3303 
Issue Date
2002
MeSH
Adult ; Aortic Valve/pathology ; Aortic Valve Insufficiency/etiology* ; Aortic Valve Insufficiency/pathology ; Behcet Syndrome/complications* ; Behcet Syndrome/drug therapy ; Behcet Syndrome/pathology ; Female ; Heart Valve Diseases/complications* ; Heart Valve Diseases/pathology ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis Implantation/mortality* ; Humans ; Immunosuppression ; Male ; Postoperative Complications ; Prosthesis Failure ; Survival Analysis
Keywords
Behçet’s disease ; aortic insufficiency ; immunosuppressive therapy
Abstract
Objectives: To assess the clinical features, pathologic findings, postoperative results and the effects of immunosuppressive therapy in patients with Behçet’s disease (BD). Methods: We reviewed the postoperative course of the 9 BD patients who underwent a total of 17 aortic valve replacement procedures with prosthetic valves. Results: Histological examination of the aortic valve commonly revealed diffuse myxoid degeneration (75 percent). Of 17 valve replacement surgeries, 13 surgeries resulted in complications, such as detachment of the prosthetic valve with perivalvular leakage and dehiscence of the sternotomy wound, within an average of 5 months (range from 1 month to 14 months). The rate of prosthetic valve detachment was 76 percent (13 of 17 surgeries). Four of the 9 patients (44 percent) who underwent aortic valve replacement procedures died of heart failure or infection associated with the detachment of the prosthetic valve, and perivalvular leakage within an average of 9 months. Aortic insufficiency associated with dehiscence of the prosthetic valve developed in 11 of 12 surgical cases (92 percent) with a mechanical valve and 2 of 5 surgical cases (40 percent) with tissue valves. Thirteen of 15 surgeries (87percent) which were not given postoperative immunosuppressive therapy developed complications, while none of 2 surgeries that used postoperative immunosuppressive therapy with prednisolone (1mg/kg/day) and azathioprine (100mg/day) had these complications. Conclusion: The rates of prosthetic valve detachment in BD involving aortic valve were higher than those of other diseases. Aortic valve involvement was also one of the poor prognostic factors in BD. Intensive postoperative immunosuppressive therapy and surgical methods may be important factors for postoperative results.
Files in This Item:
T200211191.pdf Download
DOI
10.3904/kjim.2002.17.1.51
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Suh, Chang Hee(서창희)
Song, Chang Ho(송창호)
Lee, Soo Kon(이수곤)
Lee, Won Ki(이원기)
Lee, Ji Soo(이지수)
Lee, Chan Hee(이찬희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144765
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