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Aortic Valve Involvement in Behcet`s Disease. A Clinical Study of 9 Patients

DC Field Value Language
dc.contributor.author이지수-
dc.contributor.author이찬희-
dc.contributor.author박용범-
dc.contributor.author서창희-
dc.contributor.author송창호-
dc.contributor.author이수곤-
dc.contributor.author이원기-
dc.date.accessioned2016-05-16T11:32:05Z-
dc.date.available2016-05-16T11:32:05Z-
dc.date.issued2002-
dc.identifier.issn1226-3303-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/144765-
dc.description.abstractObjectives: To assess the clinical features, pathologic findings, postoperative results and the effects of immunosuppressive therapy in patients with Behçet’s disease (BD). Methods: We reviewed the postoperative course of the 9 BD patients who underwent a total of 17 aortic valve replacement procedures with prosthetic valves. Results: Histological examination of the aortic valve commonly revealed diffuse myxoid degeneration (75 percent). Of 17 valve replacement surgeries, 13 surgeries resulted in complications, such as detachment of the prosthetic valve with perivalvular leakage and dehiscence of the sternotomy wound, within an average of 5 months (range from 1 month to 14 months). The rate of prosthetic valve detachment was 76 percent (13 of 17 surgeries). Four of the 9 patients (44 percent) who underwent aortic valve replacement procedures died of heart failure or infection associated with the detachment of the prosthetic valve, and perivalvular leakage within an average of 9 months. Aortic insufficiency associated with dehiscence of the prosthetic valve developed in 11 of 12 surgical cases (92 percent) with a mechanical valve and 2 of 5 surgical cases (40 percent) with tissue valves. Thirteen of 15 surgeries (87percent) which were not given postoperative immunosuppressive therapy developed complications, while none of 2 surgeries that used postoperative immunosuppressive therapy with prednisolone (1mg/kg/day) and azathioprine (100mg/day) had these complications. Conclusion: The rates of prosthetic valve detachment in BD involving aortic valve were higher than those of other diseases. Aortic valve involvement was also one of the poor prognostic factors in BD. Intensive postoperative immunosuppressive therapy and surgical methods may be important factors for postoperative results.-
dc.description.statementOfResponsibilityopen-
dc.format.extent51~56-
dc.relation.isPartOfKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAortic Valve/pathology-
dc.subject.MESHAortic Valve Insufficiency/etiology*-
dc.subject.MESHAortic Valve Insufficiency/pathology-
dc.subject.MESHBehcet Syndrome/complications*-
dc.subject.MESHBehcet Syndrome/drug therapy-
dc.subject.MESHBehcet Syndrome/pathology-
dc.subject.MESHFemale-
dc.subject.MESHHeart Valve Diseases/complications*-
dc.subject.MESHHeart Valve Diseases/pathology-
dc.subject.MESHHeart Valve Diseases/surgery-
dc.subject.MESHHeart Valve Prosthesis Implantation/mortality*-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppression-
dc.subject.MESHMale-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHProsthesis Failure-
dc.subject.MESHSurvival Analysis-
dc.titleAortic Valve Involvement in Behcet`s Disease. A Clinical Study of 9 Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorChoong Won Lee-
dc.contributor.googleauthorJisoo Lee-
dc.contributor.googleauthorWon Ki Lee-
dc.contributor.googleauthorChan Hee Lee-
dc.contributor.googleauthorChang Hee Suh-
dc.contributor.googleauthorChang Ho Song-
dc.contributor.googleauthorYong Beom Park-
dc.contributor.googleauthorSoo Kon Lee-
dc.contributor.googleauthorYong Soon Won-
dc.identifier.doi10.3904/kjim.2002.17.1.51-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03191-
dc.contributor.localIdA03239-
dc.contributor.localIdA01579-
dc.contributor.localIdA01920-
dc.contributor.localIdA02071-
dc.contributor.localIdA02889-
dc.contributor.localIdA02998-
dc.relation.journalcodeJ02883-
dc.identifier.eissn2005-6648-
dc.identifier.pmid12014213-
dc.subject.keywordBehçet’s disease-
dc.subject.keywordaortic insufficiency-
dc.subject.keywordimmunosuppressive therapy-
dc.contributor.alternativeNameLee, Ji Soo-
dc.contributor.alternativeNameLee, Chan Hee-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSuh, Chang Hee-
dc.contributor.alternativeNameSong, Chang Ho-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameLee, Won Ki-
dc.contributor.affiliatedAuthorLee, Ji Soo-
dc.contributor.affiliatedAuthorLee, Chan Hee-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorSuh, Chang Hee-
dc.contributor.affiliatedAuthorSong, Chang Ho-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.contributor.affiliatedAuthorLee, Won Ki-
dc.rights.accessRightsfree-
dc.citation.volume17-
dc.citation.number1-
dc.citation.startPage51-
dc.citation.endPage56-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF INTERNAL MEDICINE, Vol.17(1) : 51-56, 2002-
dc.identifier.rimsid53018-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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