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Pseudomonas aeruginosa anaerobic respiration in biofilms: Relationships to cystic fibrosis pathogenesis

Authors
 Sang Sun Yoon  ;  Robert F. Hennigan  ;  George M. Hilliard  ;  Urs A. Ochsner  ;  Kislay Parvatiyar  ;  Moneesha C. Kamani  ;  Holly L. Allen  ;  Teresa R. DeKievit  ;  Paul R. Gardner  ;  Ute Schwab  ;  John J. Rowe  ;  Barbara H. Iglewski  ;  Timothy R. McDermott  ;  Ronald P. Mason  ;  Daniel J. Wozniak  ;  Robert E.W. Hancock  ;  Matthew R. Parsek  ;  Terry L. Noah  ;  Richard C. Boucher  ;  Daniel J. Hassett 
Citation
 DEVELOPMENTAL CELL, Vol.3(4) : 593-603, 2002 
Journal Title
 DEVELOPMENTAL CELL 
ISSN
 1534-5807 
Issue Date
2002
MeSH
Anaerobiosis ; Biofilms/growth & development* ; Cystic Fibrosis/etiology ; Cystic Fibrosis/microbiology* ; Humans ; Pseudomonas aeruginosa/physiology*
Abstract
Recent data indicate that cystic fibrosis (CF) airway mucus is anaerobic. This suggests that Pseudomonas aeruginosa infection in CF reflects biofilm formation and persistence in an anaerobic environment. P. aeruginosa formed robust anaerobic biofilms, the viability of which requires rhl quorum sensing and nitric oxide (NO) reductase to modulate or prevent accumulation of toxic NO, a byproduct of anaerobic respiration. Proteomic analyses identified an outer membrane protein, OprF, that was upregulated approximately 40-fold under anaerobic versus aerobic conditions. Further, OprF exists in CF mucus, and CF patients raise antisera to OprF. An oprF mutant formed poor anaerobic biofilms, due, in part, to defects in anaerobic respiration. Thus, future investigations of CF pathogenesis and therapy should include a better understanding of anaerobic metabolism and biofilm development by P. aeruginosa.
Full Text
http://www.sciencedirect.com/science/article/pii/S1534580702002952
DOI
10.1016/S1534-5807(02)00295-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144738
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