0 399

Cited 12 times in

The Role of Mitogen-Activated Protein Kinases and Their Relationship with NF-κB and PPARγ in Indomethacin-Induced Apoptosis of Colon Cancer Cells

Authors
 Tae Il Kim  ;  Soo Hyun Jin  ;  Eun Hye Kang  ;  Sung Kwan Shin  ;  Kang Yell Choi  ;  Won Ho Kim 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.973(1) : 241-245, 2002 
Journal Title
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 
ISSN
 0077-8923 
Issue Date
2002
MeSH
Apoptosis/drug effects* ; Colonic Neoplasms/pathology* ; Humans ; Indomethacin/pharmacology* ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology* ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism* ; Receptors, Cytoplasmic and Nuclear/metabolism* ; Transcription Factors/metabolism* ; Tumor Cells, Cultured
Keywords
indomethacin ; apoptosis ; mitogen‐activated protein kinases
Abstract
We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor κB (NF-κB) and peroxisome proliferator-activated receptor γ (PPARγ) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-κB suppression and PPARγ activation.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2002.tb04641.x/abstract
DOI
10.1111/j.1749-6632.2002.tb04641.x
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Hye(강은혜)
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Jin, Soo Hyun(진수현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144693
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links