Cited 36 times in
An infection-preventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles: physical and biological properties
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이종은 | - |
dc.date.accessioned | 2016-05-16T11:29:24Z | - |
dc.date.available | 2016-05-16T11:29:24Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0160-564X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/144664 | - |
dc.description.abstract | An infection-preventing bilayered membrane consisting of a dense and porous collagen membrane has been developed. The membrane was fabricated using a combined freeze-drying/air-drying method. Hyaluronan (HA) microparticles containing silver sulfadiazine (AgSD) were fabricated by gelling an HA solution with calcium chloride and were incorporated into collagen layers to allow the sustained release of AgSD. In vitro biodegradability of the membrane and the release of AgSD from the membrane could be controlled by cross-linking the membrane with ultraviolet (UV) irradiation. In a cytotoxicity test, cellular damage was minimized by the sustained release of AgSD from dressings. The antibacterial capacity of the material against Pseudomonas aeruginosa was investigated using the Bauer-Kirby disk diffusion test, and bacterial growth was found to be inhibited for 4 days. In vivo tests showed that the bilayered membrane was associated with greater tissue regeneration than a polymeric membrane and with no infection-related biological signs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 636~646 | - |
dc.relation.isPartOf | ARTIFICIAL ORGANS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Infections/prevention & control* | - |
dc.subject.MESH | Biodegradation, Environmental | - |
dc.subject.MESH | Calcium Chloride | - |
dc.subject.MESH | Collagen* | - |
dc.subject.MESH | Drug Carriers* | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | Hyaluronic Acid/administration & dosage* | - |
dc.subject.MESH | Microscopy, Electron, Scanning | - |
dc.subject.MESH | Occlusive Dressings* | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Pseudomonas aeruginosa/drug effects | - |
dc.subject.MESH | Silver Sulfadiazine/administration & dosage* | - |
dc.title | An infection-preventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles: physical and biological properties | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Jong-Eun Lee | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Joong-Gon Kim | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.identifier.doi | 10.1046/j.1525-1594.2002.06847.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00246 | - |
dc.identifier.eissn | 1525-1594 | - |
dc.identifier.pmid | 12081522 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1046/j.1525-1594.2002.06847.x/abstract | - |
dc.subject.keyword | Antibacterial capacity | - |
dc.subject.keyword | Bilayered collagen membrane | - |
dc.subject.keyword | Cytotoxicity | - |
dc.subject.keyword | Hyaluronan microparticles | - |
dc.subject.keyword | Regeneration | - |
dc.subject.keyword | Silver sulfadiazine | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 26 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 636 | - |
dc.citation.endPage | 646 | - |
dc.identifier.bibliographicCitation | ARTIFICIAL ORGANS, Vol.26(7) : 636-646, 2002 | - |
dc.identifier.rimsid | 51349 | - |
dc.type.rims | ART | - |
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