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Compressed Spectral Array 감시하의 쥐의 중뇌동맥 일시적 폐쇄로 유발된 국소적 뇌허혈에 대한 Thiopental, Propofol, Dantrolene의 뇌보호효과의 비교

Other Titles
 Comparison of the Cerebral Protective Effects of Thiopental, Propofol and Dantrolene on Focal Cerebral Ischemia Induced by Temporary Middle Cerebral Artery Occlusion in the Rat Under the Monitoring of Compressed Spectral Array 
Authors
 김종훈  ;  김선호  ;  민경태  ;  김명희  ;  송숙근  ;  이배환 
Citation
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.32(3) : 239-245, 2002 
Journal Title
 Journal of Korean Neurosurgical Society (대한신경외과학회지) 
ISSN
 1225-8245 
Issue Date
2002
Keywords
Focal cerebral ischemia ; Thiopental ; Propofol ; Dantrolene ; Compressed spectral array
Abstract
Objective:We evaluate the cerebral protective effect of thiopental, propofol and dantrolene in middle cerebral artery occlusion(MCAO) model of rats, which ventilated spontaneously and showed definitely decreased EEG activities which is compatible with cerebral focal ischemia. Methods:Sprague-Dawley rats were anesthetized with halothane. In control group, halothane(1-1.3 vol%) was inhaled by mask. In thiopental and propofol group, halothane was switched to each drug about 20 minutes before MCAO. In dantrolene group, dantrolene was administered 20 minutes before MCAO with halothane inhalation. Middle cerebral artery was occluded for 120 minutes. The focal ischemic proess was confirmed by ipsilateral suppression of EEG, expressed by compressed spectral array. The volume percentage of infarcted brain was measured. Results:The percentage of infarct volume in thiopental group(13.7±4.6%) was significantly smaller than other groups(control group : 28.4±4.2%, propofol group:32.3±6.7%, dantrolene group : 31.9±5.4%). But, there was no statistically meaningful difference between control group, propofol group, and dantrolene group. Conclusion:The results of this study indicate that only thiopental has brain protective effect against focal cerebral ischemia.
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Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myung Hee(김명희)
Kim, Sun Ho(김선호) ORCID logo https://orcid.org/0000-0003-0970-3848
Kim, Jong Hoon(김종훈)
Min, Kyeong Tae(민경태) ORCID logo https://orcid.org/0000-0002-3299-4500
Song, Sook Keun(송숙근)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144620
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