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위암 환자의 암조직과 혈청내 혈관내피 성장인자의 발현과 임상병리학적 소견 및 예후와의 상관관계

Other Titles
 Expression of Vascular Endothelial Growth Factor in Cancer Tissues and Serum of Gastric Cancer Patients Correlation with Clinicopathologic Findings and Prognosis 
Authors
 류창학  ;  금주섭  ;  노성훈  ;  김충배  ;  이광형  ;  양우익 
Citation
 JOURNAL OF THE KOREAN SURGICAL SOCIETY , Vol.62(1) : 43-51, 2002 
Journal Title
 JOURNAL OF THE KOREAN SURGICAL SOCIETY 
ISSN
 1226-0053 
Issue Date
2002
Keywords
Gastric cancer ; Vascular endothelial growth factor ; Prognostic factor ; 위암 ; 혈관내피성장인자 ; 예후인자
Abstract
Purpose : Vascular endothelial growth factor (VEGF) is known to be produced by various malignant tumors and thought to be involved in microvascular permeability and angiogenesis. However, the clinicopathologic significance of the expression of VEGF in gastric cancer remains unclear. Methods : To examine the relationship between VEGF expression in gastric cancer and clinicopathologic factors or patient survival, tumor VEGF expression was assessed by immunohistochemical study in 144 gastric cancer patients. In addition, serum VEGF (S-VEGF) level was measured by enzyme-linked immunosorbent assay in 116 patients and in 32 healthy controls. Results : Positive staining for VEGF was observed in 68.8% (99 out of 144) of gastric cancers, and its expression was observed more frequently in patients with intestinal type and serosal invasion tumors. However, there was no significant correlation between the patients’ survival and VEGF positivity. Significant differences in preoperative S-VEGF level were found between healthy controls and patients with gastric cancer (P=0.014), whereas there was no significant difference in the S-VEGF level between control and curative resection group. When S-VEGF levels were compared between groups categorized by different clinicopathologic variables, a significant correlation was found between a high S-VEGF level and a tumor size greater than 5 ㎝, serosal invasion, lymph node and distant metastasis. Moreover, postoperative S-VEGF levels were significantly elevated as compared to preoperative levels (P=0.000). When the median S-VEGF level was used as a cutoff level, the survival rate of patients with elevated S-VEGF levels was significantly lower than that of patients with low levels (P=0.001). Conclusion : These results demonstrate that a high preoperative S-VEGF level is associated with tumor progression, metastasis and a poor outcome in patients with gastric cancer. Further studies are warranted to determine the clinical value of S-VEGF as an tumor marker and an indicator of tumor angiogenesis in gastric cancer.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144399
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