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The effect of phenylephrine and norepinephrine in patients with chronic pulmonary hypertension

Authors
 Y. L. Kwak  ;  C. S. Lee  ;  Y. H. Park  ;  Y. W. Hong 
Citation
 Anaesthesia, Vol.57(1) : 9-14, 2002 
Journal Title
 Anaesthesia 
ISSN
 0003-2409 
Issue Date
2002
MeSH
Adult ; Chronic Disease ; Female ; Heart Septal Defects/surgery ; Heart Valve Prosthesis Implantation ; Hemodynamics/drug effects ; Humans ; Hypertension, Pulmonary/complications* ; Hypertension, Pulmonary/physiopathology ; Hypotension/drug therapy* ; Hypotension/etiology ; Intraoperative Complications/drug therapy* ; Male ; Middle Aged ; Norepinephrine/therapeutic use* ; Phenylephrine/therapeutic use* ; Vasoconstrictor Agents/therapeutic use*
Keywords
Blood pressure: pulmonary ; hypertension Drug: phenylephrine ; norepinephrine
Abstract
In this study the effect of phenylephrine and norepinephrine for the treatment of systemic hypotension were evaluated in patients with chronic pulmonary hypertension. When systemic hypotension (systolic arterial pressure < 100 mmHg) occurred following induction of anaesthesia, either phenylephrine or norepinephrine were infused in a random manner to raise the systolic blood pressure by 30% and 50% above baseline values. Norepinephrine decreased the ratio of pulmonary arterial pressure to systemic blood pressure without a change in cardiac index. However, phenylephrine did not increase arterial blood pressure by more than 30% from baseline in one-third of patients and decreased cardiac index without a significant decrease in ratio of pulmonary arterial pressure to systemic blood pressure. These vasoconstrictors showed different systemic and pulmonary haemodynamic effects in patients with chronic pulmonary hypertension as compared to acute pulmonary hypertension. Norepinephrine was considered to be preferable to phenylephrine for the treatment of hypotension in patients with chronic pulmonary hypertension.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2044.2002.02324.x/abstract
DOI
10.1046/j.1365-2044.2002.02324.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Park, Young Hwan(박영환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/144391
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